ArticleBMC pediatrics2026
Effect of birth timing on early morbidity and mortality in very preterm neonates: a single-center retrospective cohort study.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreterm birth is the leading cause of neonatal mortality and morbidity worldwide. Very preterm neonates born between 23 + 0 and 31 + 6 weeks of gestational age are at particularly high risk due to complications requiring immediate intervention. Whether the differential organization of healthcare services during working hours (full staffing) versus off-hours (on-call) affects neonatal outcomes remains debated. This study aims to evaluate the effect of in-hours versus off-hours birth timing on early morbidity and mortality in very preterm neonates.
methodsThis was a single-center, retrospective cohort study conducted in a tertiary neonatal intensive care unit between January 1, 2014 and December 31, 2021. A total of 326 very preterm neonates born between 23 + 0 and 31 + 6 weeks of gestational age were included. Neonates were divided into two groups according to birth timing: Group 1 (In-hours: 08:00-17:00 on weekdays) and Group 2 (Off-hours: 17:01-07:59 on weekdays, weekends, and public holidays). Demographic data and neonatal outcomes were compared between groups, and risk factors for mortality were examined using multivariate logistic regression analysis.
resultsNo statistically significant difference was found between groups regarding gestational age, birth weight, or in-hospital mortality (Group 1: 25.3% vs. Group 2: 23.2%, p = 0.658). However, maternal risk factors such as gestational hypertension (p = 0.005) and placental insufficiency (p = 0.001) were significantly higher in the in-hours group. In multivariate analysis, low 5-minute Apgar scores and advanced-stage NEC (stage ≥ 3 A) were identified as independent risk factors for mortality in both groups. Advanced-stage NEC showed a high odds ratio in both cohorts, though accompanied by wide confidence intervals due to small event sizes.
conclusionsBirth timing (in-hours versus off-hours) had no significant effect on overall mortality or major morbidity in very preterm neonates, reflecting the continuity of care standards at our center. Advanced-stage NEC remained a critical predictor of mortality across both groups, independent of birth timing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.