Observational studyBMC gastroenterology2026
Prevalence and clinical determinants of diabetic gastroparesis in type 2 diabetes: a symptom- and scintigraphy-based cross-sectional study.
Observational study in BMC gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05584462 (Prevalence Of Gastroparesis In Type2 Diabetic Patients In Assiut University Hospital And Value Of Nuclear Imaging In Diagnosis), which is not on this map. Not yet cited in PubMed.
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Prevalence Of Gastroparesis In Type2 Diabetic Patients In Assiut University Hospital And Value Of Nuclear Imaging In Diagnosis
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Abstract
backgroundDiabetic gastroparesis (DG) is a frequently underdiagnosed complication of type 2 diabetes mellitus (T2D), characterized by delayed gastric emptying without mechanical obstruction. Its nonspecific symptoms often lead to delayed diagnosis and suboptimal management.
objectiveTo assess the prevalence and clinical predictors of DG in patients with T2D, and to investigate the relationship between gastrointestinal symptoms and objectively measured delayed gastric emptying.
methodsA cross-sectional study included 130 randomly selected patients with T2D attending a tertiary care outpatient clinic. Comprehensive clinical assessment, metabolic profiling, and screening for diabetes-related complications were performed. Symptoms suggestive of DG were assessed using the Gastroparesis Cardinal Symptom Index (GCSI), while delayed gastric emptying was objectively confirmed using gastric emptying scintigraphy (GES) with a standardized low-fat radiolabeled meal.
resultsDelayed gastric emptying was observed in 13.1% of participants. Patients with delayed gastric emptying had significantly higher body mass index (BMI), longer duration of diabetes, and poorer glycemic control compared with those without delayed emptying (all p < 0.05). Multivariate analysis identified HbA1c (OR 6.99), BMI (OR 3.89), and duration of diabetes (OR 2.75) as independent predictors of delayed gastric emptying. Symptom-based gastroparesis according to GCSI showed limited agreement with scintigraphic delayed gastric emptying.
conclusionDG appears to be a clinically relevant but potentially underrecognized complication of T2D. Poor glycemic control, obesity, and longer duration of diabetes are associated with delayed gastric emptying. Limited agreement between symptom severity and objectively measured gastric emptying supports the continued role of gastric emptying scintigraphy as the diagnostic reference standard. CLINICAL TRIAL REGISTRY: ClinicalTrials.gov (U.S. National Library of Medicine registry) CLINICAL TRIAL NUMBER: NCT05584462.
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