Evidence map›Paper›PMID 42298398›Full record

ArticleBMC microbiology2026

2''-O-galloylhyperin as a novel adjuvant to reduce imipenem resistance in multidrug-resistant Pseudomonas aeruginosa: transcriptome-based mechanism of iron homeostasis disruption.

Lin Zheng, Ge-Jin Lu, Zi-Xian Wang, Xue-Jun Guo, Zhen Wang, Zhi-Ying Shao, Ye-Tao Wang, Hua-Bin Jiang, Shu-Tian Chen, Feng-Yi Wang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lin Zheng *School of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China.
Ge-Jin Lu *Key Laboratory of Jilin Province for Zoonoses Prevention and Control, State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Changchun, Jilin, 130000, China.
Zi-Xian WangKey Laboratory of Jilin Province for Zoonoses Prevention and Control, State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Changchun, Jilin, 130000, China.
Xue-Jun GuoKey Laboratory of Jilin Province for Zoonoses Prevention and Control, State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Changchun, Jilin, 130000, China.
Zhen WangSchool of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China.
Zhi-Ying ShaoSchool of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China.
Ye-Tao WangSchool of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China.
Hua-Bin JiangSchool of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China.
Shu-Tian ChenSchool of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China.
Feng-Yi WangKey Laboratory of Jilin Province for Zoonoses Prevention and Control, State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Changchun, Jilin, 130000, China.
Jing LiQinghai Center for Animal Disease Prevention and Control, Xining, 810003, China.
Yuan-Qing LinQinghai Center for Animal Disease Prevention and Control, Xining, 810003, China.
Si-Si ZhengQinghai Center for Animal Disease Prevention and Control, Xining, 810003, China.
Guang-Hui LuSchool of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China. 380335460@qq.com.
Jun-Feng QiSchool of Biological and Food Engineering, Huanghuai University, Zhumadian, 463000, China. 1243377523@qq.com.
Ling-Wei ZhuKey Laboratory of Jilin Province for Zoonoses Prevention and Control, State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, Changchun, Jilin, 130000, China. lingweiz@163.com.

Funding

Qinghai Science and Technology Achievement Transformation Special Project 2025-NK-112the Cultivation Fund for National Scientific Research Projects of Huanghuai University XKPY-2025013the Henan Province Science and Technology Tackling Key Projects 262102310423the Henan Province Science and Technology Tackling Key Projects 262102321126
6 · The paper itself

Abstract

Imipenem, a critical antibiotic for treating multidrug-resistant Pseudomonas aeruginosa, now faces severe resistance from this pathogen. This study investigates the synergistic effects and underlying mechanisms of the combination of 2''-O-galloylhyperin with imipenem against P. aeruginosa. 2''-O-galloylhyperin showed no significant effect on the growth curve of strain 18102011 and its transconjugant D2011, while reducing the MIC of imipenem against this strain by 4-fold (FICI ≤ 0.5, synergy). This compound upregulates the citrate synthase gene gltA, and downregulates the aconitase gene acnA, enhancing citric acid synthesis while inhibiting its dehydration to cis-aconitase acid. Citric acid chelates Fe

Indexed as

Anti-Bacterial AgentsDrug Resistance, Multiple, BacterialImipenemIronPseudomonas aeruginosaBacterial Proteinsbeta-LactamasesDrug SynergismGene Expression Regulation, BacterialHomeostasisMicrobial Sensitivity TestsTranscriptomeAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesImipenemIron2’’-O-galloylhyperinImipenemOxidative damagePseudomonas aeruginosa

Identifiers

PMID42298398
PMCPMC13501639

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.