ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Sleep and dementia: Assessing established dementia-related factors using multivariable Mendelian randomization.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThe relationship between sleep, other dementia risk factors, and dementia remains unclear. We aim to explore these associations using a two-sample Mendelian randomization (MR) approach.
methodsWe identified genetic instrumental variables for sleep characteristics from the UK Biobank and obtained summary-level genetic association data for dementia outcomes, including Alzheimer's disease (AD), from the FinnGen consortium. We applied inverse-variance weighted (IVW) MR to examine the associations between sleep characteristics and dementia outcomes. Multivariable MR was subsequently employed to assess the influence of additional dementia-relevant factors on these relationships.
resultsGenetic variants for insomnia, among the sleep characteristics, were associated with elevated AD risk (odds ratio [OR] DISCUSSION: These findings indicate that the association between insomnia and AD is complex and indirect, potentially operating through social-behavioral factors (education) and biological pathways such as LDL cholesterol.
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