Evidence map›Paper›PMID 42298279›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2026

The impact of cognitive behavioral therapy for insomnia on cognitive performance and amyloid beta in older adults: A randomized controlled trial.

Catherine F Siengsukon, Lauren K Hand, Eryen Nelson, Allison Glaser, Rebecca Ludwig, Julia A Russell, Milind A Phadnis, Junqiang Dai, Jared Bruce, Eric D Vidoni and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03954210 (SIESTA), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03954210 nacompletednot on this map

SIESTA: Sleep Intervention to Enhance Cognitive Status and Reduce Beta Amyloid

TypeinterventionalSponsorUniversity of Kansas Medical CenterRan2019 to 2025Enrolled200ConditionsInsomniaArmsCognitive Behavioral Therapy for Insomnia (CBT-I), Sleep and Lifestyle Education
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Catherine F SiengsukonDepartment of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, Kansas, USA.
Lauren K HandDepartment of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, Kansas, USA.
Eryen NelsonDepartment of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, Kansas, USA.
Allison GlaserDepartment of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, Kansas, USA.
Rebecca LudwigDepartment of Physical Therapy, Rehabilitation Science, and Athletic Training, University of Kansas Medical Center, Kansas City, Kansas, USA.
Julia A RussellDepartment of Psychology, University of Kansas, Lawrence, Kansas, USA.
Milind A PhadnisDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.
Junqiang DaiDepartment of Biostatistics & Data Science, University of Kansas Medical Center, Kansas City, Kansas, USA.
Jared BruceDepartment of Biomedical and Health Informatics, University of Missouri-Kansas City, School of Medicine, Kansas City, Missouri, USA.
Eric D VidoniUniversity of Kansas Alzheimer's Disease Research Center, Fairway, Kansas, USA.
Michelle DrerupNeurological Institute, Sleep Disorders Center, Cleveland Clinic, Cleveland, Ohio, USA.
Jill MorrisDepartment of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Jeffrey M BurnsUniversity of Kansas Alzheimer's Disease Research Center, Fairway, Kansas, USA.

Funding

University of Kansas Alzheimer's Disease Research Center (KU ADRC)P30AG072973 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Jaime Perales Puchalt · 2021 to 2026
$25.3M
Nutrition, Obesity and Atherosclerosis Training ProgramT32HL007028 · NHLBI · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1985 to 2026
$6.4M
Primary Prevention of Alzheimer's disease: Examining the effects of cognitive behavioral therapy on cognitive function and amyloid-beta in older adults with symptoms of insomniaR01AG058530 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SIENGSUKON, CATHERINE F · 2019 to 2023
$3.7M
Multidisciplinary Research Training Program in Alzheimer's Disease and Related DisordersT32AG078114 · NIA · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Sandra A Billinger, Eric Dennis Vidoni · 2022 to 2026
$1.2M
Eunice Kennedy Shriver National Institute of Child Health and Human Development T32HD057850NIA NIH HHS P30 AG072973NIA NIH HHS R01AG058530NIA NIH HHS T32 AG078114NIH HHS T32HL007028
6 · The paper itself

Abstract

introductionInsomnia is associated with increased risk for Alzheimer's disease (AD). It is unknown how cognitive behavioral therapy for insomnia (CBT-I) impacts two hallmarks of AD progression, cognitive performance and beta-amyloid (Aβ) burden.

methodsCognitively normal older adults with symptoms of insomnia were randomized into CBT-I treatment (n = 100) or control (n = 100) groups. Cognitive performance was assessed at baseline, 6-weeks, and 1-year (1 year). Aβ burden was assessed in a subsample (n = 50).

resultsNo differences were observed between groups in change in cognitive performance, including speed of information processing (mean difference, 0.017; 95% confidence interval [CI], -0.1036 to 0.1376; p = 0.78), executive function (-0.0881; 95% CI, -0.2945 to 0.1182; p = 0.40), and memory (0.4068; 95% CI, -2.3965 to 3.2101; p = 0.77). No group differences were observed in Aβ deposition. DISCUSSION: CBT-I did not improve cognitive performance or Aβ deposition by one year. Longer follow up is needed to understand the potential impact of CBT-I on AD risk. CLINICAL

trial registrationThe study was registered on clinicaltrials.gov (NCT03954210) on 5/17/2019.

Indexed as

Amyloid beta-PeptidesCognitionCognitive Behavioral TherapySleep Initiation and Maintenance DisordersAgedAged, 80 and overAlzheimer DiseaseExecutive FunctionFemaleHumansMaleNeuropsychological TestsAmyloid beta-PeptidesAlzheimer's diseasebeta‐amyloidcognitive behavioral therapycognitive performancedementiainsomnia

Identifiers

PMID42298279
PMCPMC13269014

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.