Evidence map›Paper›PMID 42298222›Full record

ArticleAnnals of biomedical engineering2026

Bile Salts and Bacterial Bile Salt Hydrolase Activity Influence Escherichia coli Colonization and FXR Signaling in Colorectal Cancer Organoids.

Ishita Dasgupta, Arianna Brevi, Yixiao Ma, Durga Prasad Rangineni, Miriam Duran, Amir Zarrinpar, Abhinav Bhushan

Abstract read
PubMed Publisher
In one paragraph

Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ishita DasguptaDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Arianna BreviDivision of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Yixiao MaDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Durga Prasad RangineniDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Miriam DuranDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA.
Amir ZarrinparDivision of Gastroenterology and Hepatology, Department of Medicine, University of California, San Diego, La Jolla, CA, USA.
Abhinav BhushanDepartment of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA. abhushan@iit.edu.ORCID http://orcid.org/0000-0002-8861-9005

Funding

Engineering Native E. coli to Detect, Report, and Treat Colorectal CancerU01CA265719 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZARRINPAR, AMIR · 2021 to 2025
$3.1M
National Science Foundation 2240045NCI NIH HHS U01 CA265719NIH HHS U01CA265719
6 · The paper itself

Abstract

Bile salts are key regulators of intestinal homeostasis and host-microbe interactions in the intestine. While bile salt hydrolase (BSH) activity is known to modulate host metabolism, the direct interplay between bile salt signaling, microbial BSH activity, bile acid signaling, and epithelial responses in colorectal cancer remains poorly understood. Here, we established a controlled in vitro co-culture platform using isogenic murine healthy and tumor-derived colon organoids to dissect bile salt-driven epithelial-microbe responses at cellular resolution. We investigated the dynamics between the host and an engineered BSH-expressing Escherichia coli strain (EcAZ-2

Indexed as

Bacteria colonizationBile saltsCell fateColorectal cancerEngineered bacteriaOrganoids

Identifiers

PMID42298222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.