ReviewAesthetic plastic surgery2026
Permanent Complications After Dermal Fillers: Risks, Prevention, and Management Strategies.
Review in Aesthetic plastic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDermal fillers are widely utilized in esthetic medicine for soft tissue augmentation and facial rejuvenation. Generally safe, complications are mostly minor. Permanent complications, though rare, are disastrous and overwhelmingly caused by insufficient understanding of facial anatomy, wrong filler selection, technique, and poor diagnosis and management. This review aims to bridge the knowledge gaps that lead to permanent complications, provide guidelines to avoid them, and create best practices to manage them should they occur.
methodsA PRISMA-guided systematic search of PubMed (2000-2024) was conducted using relevant search terms of English-language publications reporting irreversible outcomes or complications of fillers persisting beyond 12 months.
resultsBlindness, stroke, chronic granulomatous inflammation, and irreversible tissue necrosis represent the most severe outcomes. The preponderance of evidence indicates that anatomic injection site, wrong technique, filler permanence, rather than injected volume alone, are the principal determinants of irreversible injury. HA fillers remain preferable due to reversibility; permanent fillers pose increased long-term complication risk. The following synthesis examines anatomically based injection safety principles, product selection criteria by location, and complication prevention strategies supported by peer-reviewed literature.
conclusionsSafe and effective dermal filler practice is grounded in anatomic precision, meticulous technique, informed product selection, and preparedness to manage complications. Continuous education, adherence to evidence-based protocols, and awareness of high-risk anatomic regions could significantly reduce adverse outcomes. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.