Evidence map›Paper›PMID 42298142›Full record

ArticleNPJ digital medicine2026

Integrating ultrasound-CT-MR for preoperative multi-task prediction in ovarian cancer: achieving diagnostic parity with multidisciplinary team consensus.

Jingjing Yu, Peijun Hu, Ruixia Dai, Xiaomin Liu, Shanshan Zhang, Yangdi Xu, Yiwei Gao, Bingjian Lu, Wenqian Wang, Yizhen Niu and 11 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Jingjing Yu *Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Peijun Hu *Research Center for Scientific Data Hub, Zhejiang Lab, Hangzhou, China.
Ruixia Dai *Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaomin LiuWomen's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Shanshan ZhangDepartment of Ultrasound, the Fourth Affiliated Hospital, Zhejiang University School of Medcine, Yiwu, China.
Yangdi XuResearch Center for Scientific Data Hub, Zhejiang Lab, Hangzhou, China.
Yiwei GaoResearch Center for Scientific Data Hub, Zhejiang Lab, Hangzhou, China.
Bingjian LuWomen's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Wenqian WangDepartment of Ultrasound, the Fourth Affiliated Hospital, Zhejiang University School of Medcine, Yiwu, China.
Yizhen NiuWomen's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Xiaochen WangSchool of Clinical Medicine, Hangzhou Normal University, Hangzhou, China.
Shihao XuDepartment of Ultrasound Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Weibin WangResearch Center for Scientific Data Hub, Zhejiang Lab, Hangzhou, China.
Qianqian QiResearch Center for Scientific Data Hub, Zhejiang Lab, Hangzhou, China.
Fan LiuResearch Center for Scientific Data Hub, Zhejiang Lab, Hangzhou, China.
Yang ZhangResearch Center for Scientific Data Hub, Zhejiang Lab, Hangzhou, China.
Sihui HuSchool of Clinical Medicine, Hangzhou Normal University, Hangzhou, China.
Yu TianEngineering Research Center of EMR and Intelligent Expert System, Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China. tyler@zju.edu.cn.
Weiguo LuWomen's Hospital, Zhejiang University School of Medicine, Hangzhou, China. lbwg@zju.edu.cn.
Jingsong LiEngineering Research Center of EMR and Intelligent Expert System, Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, China. ljs@zju.edu.cn.
Jiale QinWomen's Hospital, Zhejiang University School of Medicine, Hangzhou, China. qinjiale@zju.edu.cn.

Funding

Medical Health Science and Technology Plan of Zhejiang Provincial Health Commission WKJ-ZJ-2408Zhejiang Key Research & Development Program 2024C03184Zhejiang Key Research & Development Program 2025SSYS0002
6 · The paper itself

Abstract

Ovarian cancer, with high mortality, demands accurate preoperative assessment to guide individualized treatment. It typically requires ultrasound, CT, and MRI interpreted by multidisciplinary teams (MDTs) in complex cases. We developed OVUCM, a multi-task AI system that integrates multi-modalities via intermediate fusion using radiomics, machine learning, and 5×4 nested cross-validation. Trained on 1742 patients from a cancer center, OVUCM predicted five clinical tasks with AUCs of 0.847-0.929: benign vs. non-benign, borderline vs. malignant, non-epithelial vs. epithelial, FIGO stages I-II vs. III-IV, and non-HGSOC vs. HGSOC. External validation in 150 patients from two general hospitals confirmed generalizability (AUCs: 0.833-0.974). The system achieved diagnostic parity with MDT consensus in four tasks and outperformed it in one, while consistently surpassing at least one independent gynecologist across all tasks. By emulating MDT-level interpretation, OVUCM bridges the gap between single-modality tools and comprehensive clinical decision-making, offering a scalable solution in resource-limited settings.

Identifiers

PMID42298142
PMCPMC13627687

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.