Evidence map›Paper›PMID 42298100›Full record

ArticleNature nanotechnology2026

Programmed synthesis of mesoporous protein crystals in cellular reactors.

Hongru Yang, Dian-Zhao Lin, Zhe Li, Yuqing Yan, Zuo-Han Zhao, Byeongdu Lee, Chang Woo Song, Shunzhi Wang, Jiaxi Lu, Yimei Wang and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature nanotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Chemical reviews · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hongru YangDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0009-0006-1212-8505
Dian-Zhao LinDepartment of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1177-2308
Zhe LiInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-9402-4940
Yuqing YanDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0009-0008-1956-4689
Zuo-Han ZhaoDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1812-6237
Byeongdu LeeX-ray Science Division, Advanced Photon Source, Argonne National Laboratory, Argonne, Lemont, IL, USA.ORCID http://orcid.org/0000-0003-2514-8805
Chang Woo SongDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-3596-3291
Shunzhi WangInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5033-7478
Jiaxi LuDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0009-0006-8502-1952
Yimei WangDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
Yongzhi SunDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-5267-6780
Ken LiviDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA.
David BakerInstitute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7896-6217
Yayuan LiuDepartment of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA. yayuanliu@jhu.edu.ORCID http://orcid.org/0000-0002-0718-4784
Dingchang LinDepartment of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA. dclin@jhu.edu.ORCID http://orcid.org/0000-0002-9354-5952

Funding

Protein assemblies as genetically encoded mechanical actuators for intracellular mechanobiology researchR35GM147274 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Dingchang Lin · 2022 to 2026
$2.0M
David and Lucile Packard Foundation (David & Lucile Packard Foundation) N/AHoward Hughes Medical Institute (HHMI) n/aKavli Foundation N/ANSF | Directorate for Mathematical & Physical Sciences | Division of Materials Research (DMR) 2348276United States Department of Defense | United States Air Force | AFMC | Air Force Office of Scientific Research (AF Office of Scientific Research) FA9550-23-1-0174U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM147274
6 · The paper itself

Abstract

Protein crystals are naturally derived mesoporous materials with versatile structures and physicochemical properties. Here we introduce an intracellular synthesis platform that enables controllable and programmable protein crystallization. In live cells, we show that, after initial nucleation, steady protein expression governs crystal growth, yielding predictable, tunable dynamics in live cells. Exploiting this feature, we combined HaloTag and click chemistries to achieve modular, programmable immobilization of diverse guest materials with spatial patterning down to ~100 nm resolution. We further demonstrated the sequential release of immobilized materials in physiologically relevant fluids. As a proof of concept, we programmed particles to carry human fibroblast growth factors in distinct layers, which elicited designed oscillatory Akt signalling patterns in cell culture. This work outlines a programmable method for producing mesoporous materials, with possible applications in catalysis and biomedicine.

Indexed as

BioreactorsFibroblast Growth FactorsCrystallizationHumansPorosityFibroblast Growth Factors

Identifiers

PMID42298100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.