Evidence map›Paper›PMID 42298064›Full record

Observational studyInternational journal of colorectal disease2026

Evaluation of the prognostic impact of intraoperative cytology results according to tumor sidedness in stage II/III resectable colorectal cancer.

Akihiro Usui, Hirotoshi Kobayashi, Kenjiro Kotake, Kotaro Maeda, Takeshi Shuto, Masayasu Kawasaki, Koji Komori, Heita Ozawa, Chihiro Kosugi, Masayuki Ohue and 13 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in International journal of colorectal disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Akihiro UsuiDepartment of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara, Chiba, 299-0111, Japan. usui.akihiro.gj@teikyo-u.ac.jp.
Hirotoshi KobayashiDepartment of Surgery, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan.
Kenjiro KotakeDepartment of Surgery, Sano City Hospital, Tochigi, Japan.
Kotaro MaedaInternational Medical Center, Fujita Health University Hospital, Toyoake, Japan.
Takeshi ShutoDepartment of Gastroenterological Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Masayasu KawasakiDepartment of Surgery, Bell Land General Hospital, Sakai, Japan.
Koji KomoriDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Aichi, Japan.
Heita OzawaDepartment of Surgery, Tochigi Cancer Center, Utsunomiya, Japan.
Chihiro KosugiDepartment of Surgery, Teikyo University Chiba Medical Center, 3426-3 Anesaki, Ichihara, Chiba, 299-0111, Japan.
Masayuki OhueDepartment of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka, Japan.
Kimihiko FunahashiDepartment of General and Gastroenterological Surgery, Toho University Omori Medical Center, Ota City, Japan.
Ichiro TakemasaDepartment of Surgery, Surgical Oncology and Science, Sapporo Medical University, Sapporo, Japan.
Hideyuki IshidaDepartment of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Shinsuke KazamaDepartment of Gastroenterological Surgery, Saitama Cancer Center, Ina-machi, Japan.
Yoshifumi ShimadaDivision of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Hajime MotohashiDepartment of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, Aomori, Japan.
Yusuke KinugasaDepartment of Gastrointestinal Surgery, Institute of Science Tokyo, Tokyo, Japan.
Yukihide KanemitsuDepartment of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.
Hiroki OchiaiDepartment of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
Soichiro IshiharaDepartment of Surgical Oncology, The University of Tokyo Hospital, Tokyo, Japan.
Michio ItabashiDepartment of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan.
Kenichi SugiharaTokyo Medical and Dental University, Tokyo, Japan.
Hideki UenoDepartment of Surgery, National Defense Medical College, Tokorozawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate whether colorectal cancer (CRC) sidedness is associated with intraoperative lavage cytology results, tumor recurrence, and prognosis.

methodUsing data from a multicenter prospective observational study conducted by the Japanese Society for Cancer of the Colon and Rectum (JSCCR), we retrospectively analyzed prognosis and recurrence patterns in pathological stage II/III right-sided and left-sided CRC, stratified by positive versus negative lavage cytology results.

resultsA total of 1500 patients met the inclusion criteria and were enrolled. Of these, 534 had right-sided CRC and 966 had left-sided CRC. Fifty-nine patients (3.9%) had positive lavage cytology. Among patients with recurrence, pT4, positive lavage cytology, and right-sided tumor location were independently associated with peritoneal recurrence. Among cytology-negative patients, the 5-year relapse-free survival (RFS) rate was significantly higher in right-sided than in left-sided CRC (79.6% vs. 73.4%, p = 0.01), whereas the 5-year overall survival (OS) rate did not differ significantly (89.2% vs. 87.7%, p = 0.52). Among cytology-positive patients, no statistically significant differences in RFS or OS were observed between tumor locations. However, among cytology-positive patients who developed recurrence, post-recurrence survival was significantly worse in right-sided CRC than in left-sided CRC (p = 0.04).

conclusionAmong cytology-negative patients, left-sided CRC was associated with poorer RFS than right-sided CRC, although OS did not differ. Right-sided tumor location and positive lavage cytology were independently associated with peritoneal recurrence among patients who developed recurrence. Among cytology-positive patients, right-sided CRC was associated with poorer post-recurrence survival.

Indexed as

Colorectal NeoplasmsCytodiagnosisAgedColorectal Surgical ProceduresDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPrognosisColorectal cancerOverall survivalRelapse-free survival

Identifiers

PMID42298064
PMCPMC13500429

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.