ArticleScientific reports2026
Uncovering the potential anti-cancer compounds from Strobilanthes cusia against colorectal cancer through network pharmacology and molecular docking.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Colorectal cancer (CRC) remains a major global health challenge owing to its therapeutic resistance and high recurrence rates, underscoring the need for mechanism-based interventions. Strobilanthes cusia (Nees) Kuntze, a medicinal herb traditionally used for inflammatory disorders, contains bioactive diterpenoids and alkaloids with anticancer potential. However, the molecular mechanisms underlying this process in CRC remain unclear. This study evaluated sequential Soxhlet extracts of S. cusia leaves using integrated in-vitro and in-silico methods. Among the n-hexane, chloroform, ethanol, and aqueous fractions, the ethanolic extract exhibited the highest cytotoxicity against HCT-116 and SW-620 CRC cells, with IC
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