Evidence map›Paper›PMID 42297979›Full record

ArticleNature medicine2026

Activity-dependent adaptive deep brain stimulation improves gait in Parkinson's disease.

Stefano Scafa, Valeria de Seta, Ruijia Wang, Paula Sánchez López, Andrea Sánchez López, Camille Varescon, Icare Sakr, Nadia Bérard, Lea Bole-Feysot, Céline Deschenaux and 17 more

Registry-linked trialAbstract readClinical Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06791902 (Study on Preliminary Safety and Efficacy of Adaptive DBS Aligned to Locomotor States to Improve Locomotor Functions in Parkinson's Patients), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06791902 narecruitingnot on this map

Study on Preliminary Safety and Efficacy of Adaptive DBS Aligned to Locomotor States to Improve Locomotor Functions in Parkinson's Patients

TypeinterventionalSponsorJocelyne BlochRan2025 to 2027Enrolled10ConditionsParkinson DiseaseArmsAdaptive DBS
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Stefano Scafa *Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0009-0003-0707-7158
Valeria de Seta *Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-8796-8775
Ruijia WangNeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-5018-5398
Paula Sánchez LópezNeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Andrea Sánchez LópezDepartment of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0009-0002-1453-6079
Camille VaresconDepartment of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Icare SakrNeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Nadia BérardDepartment of Neurosurgery, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-2082-4221
Lea Bole-FeysotDepartment of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Céline DeschenauxDepartment of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Ian EnderliNeuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.
Yohann ThenaisieDepartment of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-9936-5821
Morgane BurriNeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Frédéric MerlosNeuroRestore, Lausanne University Hospital (CHUV) and Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID http://orcid.org/0009-0008-1018-5260
Vanessa FleuryDepartment of Neurology, Hôpitaux Universitaires de Genève (HUG), Geneva, Switzerland.
Benoit WickiDepartment of Neurology, Hôpital du Valais, Sion, Switzerland.
Ettore AccollaDepartment of Neurology, Hôpital Fribourgeois, Fribourg, Switzerland.
Andria TziakouriDepartment of Neurology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Cécile HübschDepartment of Neurology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Mayte Castro JiménezDepartment of Neurology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0003-4165-4804
Julien F BallyDepartment of Neurology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-0970-8844
Alessandro PuiattiInstitute of Digital Technologies for Personalized Healthcare (MeDiTech), University of Southern Switzerland (SUPSI), Viganello, Switzerland.ORCID http://orcid.org/0000-0002-9745-1515
Kyuhwa LeeWyss Center for Bio and Neuroengineering, Geneva, Switzerland.ORCID http://orcid.org/0000-0002-3854-4690
Henri LorachDepartment of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Antoine Collomb-ClercNeuro-X Institute, École Polytechnique Fédérale de Lausanne (EPFL), Geneva, Switzerland.ORCID http://orcid.org/0000-0002-5687-0852
Jocelyne Bloch *Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.ORCID http://orcid.org/0000-0002-6405-1590
Eduardo M Moraud *Department of Clinical Neurosciences, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland. Eduardo.Moraud@epfl.ch.ORCID http://orcid.org/0000-0002-6148-7065

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) TMSGI3_218471
6 · The paper itself

Abstract

Parkinson's disease leads to a spectrum of locomotor deficits that vary in severity with the nature of daily activities and the fluctuating physiology of patients. Many of these deficits remain inadequately addressed by existing deep brain stimulation therapies that rely on activity-agnostic parameters optimized for cardinal motor symptoms. By contrast, therapies embedding activity-specific parameters have the potential to better address the entire range of symptoms. Here we expose physiological principles that enable real-time decoding of ongoing locomotor activities across motor fluctuations from the neural dynamics of the subthalamic nucleus. This decoding steered activity-dependent adaptations of deep brain stimulation therapies that improved locomotor deficits while preserving efficacy for cardinal motor symptoms across activities of daily living. Our activity-dependent framework provides a blueprint for next-generation neuromodulation therapies that continuously select parameters optimized to the behavioral context and fluctuating physiology of each patient. ClinicalTrials.gov registration NCT06791902 .

Indexed as

Deep Brain StimulationGaitParkinson DiseaseActivities of Daily LivingHumansSubthalamic Nucleus

Identifiers

PMID42297979
PMCPMC13472876

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.