Evidence map›Paper›PMID 42297942›Full record

ArticleScientific reports2026

Metabolic expenditure, neurodevelopment, and weight gain into early childhood after fetal growth restriction.

Cigdem Gelegen, Beatrice Copley, Neelum Mistry, Chiara Sacchi, Chiara Nosarti, Lorenzo Fabrizi, Anna L David, Kimberley Whitehead

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cigdem Gelegen *Elizabeth Garrett Anderson Institute for Women's Health, University College London, London, WC1E 6AU, UK.
Beatrice Copley *Research Division of Digital Health and Applied Technology Assessment (DHATA), King's College London, London, SE1 8WA, UK.
Neelum Mistry *Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, UK.
Chiara SacchiDepartment of Developmental Psychology and Socialisation, University of Padua, Padua, 35122, Italy.
Chiara NosartiDepartment of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, SE1 7EH, UK.
Lorenzo FabriziDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, UK.
Anna L DavidElizabeth Garrett Anderson Institute for Women's Health, University College London, London, WC1E 6AU, UK.
Kimberley WhiteheadElizabeth Garrett Anderson Institute for Women's Health, University College London, London, WC1E 6AU, UK. kimberley.whitehead@kcl.ac.uk.

Funding

Medical Research Council MR/S026460/1Medical Research Council MR/X010716/1
6 · The paper itself

Abstract

Fetal growth restriction (FGR) subjects exhibit altered metabolism, with higher metabolic rate due to their small body mass, and by adopting strategies to minimise energy expenditure. We investigated how these metabolic differences develop, or manifest in growth trajectories, after FGR, small for gestational age (SGA) with no evidence of FGR, and normal pregnancies. We curated a unique composite dataset of subjects between 14 weeks of gestation and six years of age. First, we assessed fetal and infant heart rate to assess whether higher metabolic rate persisted postnatally after FGR. Next, as the largest energy expenditure is brain synaptic maintenance, we tested whether FGR infants had lower white matter volume (proxy for synapse number). Finally, we modelled longitudinal body weight into childhood in FGR, SGA, and control groups, and tested for associations with neurodevelopmental scores at 1-2 years. Heart rate at rest was 3.2 beats per minute higher in FGR fetuses and infants (710 subjects), and FGR infants exhibited only 52% the increase in heart rate to a nociceptive procedure (i.e. a physiological challenge) observed in controls. FGR infants had 7 cm

Indexed as

Energy MetabolismFetal Growth RetardationWeight GainChildChild, PreschoolFemaleHeart RateHumansInfantInfant, NewbornInfant, Small for Gestational AgeMaleNeurodevelopmentPregnancyWhite MatterAutonomicDevelopmental origins of health and diseaseIntrauterine growth restrictionNeonatalPlacental insufficiencyPrematurity

Identifiers

PMID42297942
PMCPMC13270132

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.