ArticleMolecular psychiatry2026
Disruption of major Ptchd1 isoforms causes autistic traits in social behavior and communication.
Sangyoon Y Ko, Stephen F Pastore, Sungmo Park, Jonathan R Epp, Anna Mikhailov, Leon French, Hidekiyo Harada, Philippe P Monnier, Paul A Hamel, Sheena A Josselyn and 2 more
Abstract read
In one paragraphArticle in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Stephen F PastoreMolecular Neuropsychiatry and Development Lab, Campbell Family Brain Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Sungmo ParkProgram in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
Jonathan R EppProgram in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, ON, Canada.
Anna MikhailovMolecular Neuropsychiatry and Development Lab, Campbell Family Brain Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Leon FrenchComputational Neurobiology Lab, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Hidekiyo HaradaDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
Philippe P MonnierDonald K. Johnson Eye Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada.
John B VincentMolecular Neuropsychiatry and Development Lab, Campbell Family Brain Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada. john.vincent@camh.ca.ORCID http://orcid.org/0000-0003-0692-2519 Funding
Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) MOP114952Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT156367Hospital for Sick Children (SickKids) Restracomp
6 · The paper itselfAbstract
PTCHD1 is an X-linked three-exon gene associated with autism spectrum disorder (ASD) and/or intellectual disability (ID). Mice lacking Ptchd1 exon 2 (Ptchd1
Indexed as
Membrane ProteinsAnimalsAutism Spectrum DisorderAutistic DisorderBehavior, AnimalBrainCommunicationDisease Models, AnimalExonsFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutMutationMembrane ProteinsProtein Isoforms
What OpenQuestion holds
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