Evidence map›Paper›PMID 42297920›Full record

ArticleScientific reports2026

Dose- and state-dependent enhancement of hippocampal CA1 pyramidal neuron excitability by GM1 ganglioside in male rats with cholinergic lesions.

Sedigheh Ashkavandi, Ahmad Ali Moazedi, Saeed Semnanian, Saeedeh Abdolahpour, Maryam Gholami

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sedigheh AshkavandiDepartment of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran. S_bio84@yahoo.com.
Ahmad Ali MoazediDepartment of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Saeed SemnanianDepartment of Physiology, Tarbiat Modares University, Tehran, Iran.
Saeedeh AbdolahpourGrowth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Maryam GholamiDepartment of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cholinergic degeneration contributes to hippocampal circuit dysfunction in Alzheimer's disease (AD). Ganglioside GM1 modulates membrane signaling and synaptic function, yet its acute effects on hippocampal neuronal activity under cholinergic-deficient conditions remain unclear. Using in vivo single-unit recordings in urethane-anesthetized male rats, extracellular single-unit activity was recorded from CA1 pyramidal neurons before and after systemic GM1 administration. We examined whether systemic GM1 alters spontaneous firing of CA1 pyramidal neurons in a nucleus basalis magnocellularis (NBM) lesion model of cholinergic hypofunction. GM1 (2, 5, 10 mg/kg, i.p.) produced dose-dependent increases in firing rate. Linear mixed-effects modeling, accounting for multiple neurons per animal, revealed a significant main effect of Time (F

Indexed as

CA1 Region, HippocampalG(M1) GangliosidePyramidal CellsAcetylcholineAction PotentialsAnimalsDose-Response Relationship, DrugMaleRatsAcetylcholineG(M1) GangliosideAlzheimer’s diseaseCA1 pyramidal neuronsCholinergic lesionGM1 gangliosideNeuronal excitabilitySingle-unit recording

Identifiers

PMID42297920
PMCPMC13530171

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.