SynthesisNature metabolism2026
Adiposity and cancer: systematic review and meta-analysis.
Synthesis in Nature metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Hypoxia-Inducible Factor-1α Gene (Cancers · 2026Article
- Reassessing the link between adiposity and head and neck cancer: a Mendelian randomization study.eLife · 2025Article
Corrections and comments
- Update of
Authors and funding
5 authors.
Funding
Abstract
Obesity is a major health challenge. Here we show that body mass index is positively associated with risk of 19 cancers and inversely associated with 3, based on a systematic review and meta-analysis of prospective studies of 25 cancer types. We searched PubMed, EMBASE and Scopus through to 23 April 2025, identifying 226 articles comprising 1.5 million incident cancers. We identified positive associations for leukaemia, non-Hodgkin lymphoma, bladder cancer and glioma, not previously identified by major consensus reports. Associations differed according to region and sex, with stronger associations for postmenopausal breast and ovarian cancers in East Asia, weaker associations for gallbladder cancer in East Asia and in men, and stronger associations for colorectal cancer in men. Body mass index and waist circumference showed similar associations with cancer. We reviewed Mendelian randomization and imaging-based studies; genetic findings were generally consistent with observational associations, while imaging data were limited. Our findings underscore the impact of obesity on cancer risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.