ArticleScientific reports2026
Aging macaques bridge the translational gap in perivascular space biology.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The brain-wide burden of MR-visible perivascular spaces (PVS) is age-dependent in rhesus macaques. Automated quantification in 94 male and female animals ranging 5-28 years of age demonstrated a robust association of age with PVS count and volume, and an anatomical distribution paralleling that of humans. Preliminary ex vivo microscopy confirmed that an MRI-detected tubular structure corresponded to a perivascular space. These findings begin to establish the rhesus macaque as a tractable model for understanding the role of perivascular function in age-related brain vulnerability.
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