Evidence map›Paper›PMID 42297817›Full record

ArticleNature communications2026

Structural basis for activation and potentiation in a human α5β3 GABA

John Cowgill, Chen Fan, Jan Steyaert, Rebecca J Howard, Erik Lindahl

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A pore-facing glycan constrains GABACommunications biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

John CowgillDepartment of Biochemistry and Biophysics, SciLifeLab, Stockholm University, Solna, Sweden. john.cowgill@scilifelab.se.ORCID 0000-0002-7968-8359
Chen FanDepartment of Applied Physics, SciLifeLab, KTH Royal Institute of Technology, Solna, Sweden.ORCID 0000-0003-1211-3427
Jan SteyaertVIB-VUB Center for Structural Biology, VIB, Brussels, Belgium.ORCID 0000-0002-3825-874X
Rebecca J HowardDepartment of Biochemistry and Biophysics, SciLifeLab, Stockholm University, Solna, Sweden. rebecca.howard@scilifelab.se.ORCID 0000-0003-2049-3378
Erik LindahlDepartment of Biochemistry and Biophysics, SciLifeLab, Stockholm University, Solna, Sweden. erik.lindahl@scilifelab.se.ORCID 0000-0002-2734-2794

Funding

Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) 2023.0254Stockholms Universitet (Stockholm University) FV-5.1.2-0523-19Vetenskapsrådet (Swedish Research Council) 2019-02433Vetenskapsrådet (Swedish Research Council) 2019-02433, 2021-05806Vetenskapsrådet (Swedish Research Council) 2021-05806
6 · The paper itself

Abstract

Anesthetics and anticonvulsants act, in part, through diverse populations of type-A ɣ-aminobutyric acid receptors (GABA

Indexed as

Receptors, GABA-AAnimalsCryoelectron MicroscopyEtomidategamma-Aminobutyric AcidHEK293 CellsHippocampusHumansModels, MolecularProtein SubunitsZincEtomidategamma-Aminobutyric AcidProtein SubunitsReceptors, GABA-AZinc

Identifiers

PMID42297817
PMCPMC13269941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.