Evidence map›Paper›PMID 42297774›Full record

ArticleTranslational psychiatry2026

Excess EEG beta-band oscillations in Dup15q syndrome correlate with clinical severity.

Joerg F Hipp, Stormy Chamberlain, Charlotte DiStefano, Joel Frohlich, Maria-Clemencia Hernandez, Vidya Saravanapandian, Vanessa Vogel-Farley, Celia Goeldner, Shafali S Jeste

Abstract read
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In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Joerg F HippRoche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center Basel, Basel, Switzerland. joerg.hipp@roche.com.ORCID http://orcid.org/0000-0002-7875-2988
Stormy ChamberlainRoche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center Basel, Basel, Switzerland.
Charlotte DiStefanoChildren's Hospital Los Angeles and University of Southern California, Department of Psychiatry, Los Angeles, California, USA.
Joel FrohlichRoche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center Basel, Basel, Switzerland.
Maria-Clemencia HernandezRoche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0003-1621-4188
Vidya SaravanapandianCenter for Autism Research and Treatment University of California, Los Angeles Semel Institute for Neuroscience, Los Angeles, USA.
Vanessa Vogel-FarleyDup15q Alliance, Highland Park, Illinois, USA.ORCID http://orcid.org/0000-0002-1010-5944
Celia GoeldnerRoche Pharma Research and Early Development, Neuroscience and Rare Diseases, Roche Innovation Center Basel, Basel, Switzerland.
Shafali S JesteChildren's Hospital Los Angeles and University of Southern California, Department of Psychiatry, Los Angeles, California, USA.

Funding

UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Peyman Golshani, SUMA JACOB · 2020 to 2026
$9.6M
UCLA Center for Translational Research in Neurodevelopment: UC-TRaNU54HD087101 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COPPOLA, GIOVANNI · 2016 to 2020
$6.5M
Electrophysiological biomarkers of sleep and cognition in Dup15q syndromeR21HD099686 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JESTE, SHAFALI SPURLING · 2019 to 2020
$410k
NICHD NIH HHS P50 HD103557NICHD NIH HHS R21 HD099686NICHD NIH HHS U54 HD087101
6 · The paper itself

Abstract

Dup15q syndrome is a rare genetic neurodevelopmental disorder caused by copy number gains of 15q11.2-q13.1, which include UBE3A and three GABA-A receptor subunit genes among several other genes. The contribution of the different genes to etiology remains elusive. Excess EEG beta-band power is a characteristic electrophysiological phenotype of this syndrome and a candidate biomarker of increased GABA-A receptor activity. Here we investigate the link between clinical and EEG phenotypes. We implemented a method to isolate oscillatory activity in the beta-band (16-32 Hz) from the background of the EEG power spectrum, i.e., locally referenced power (LRP

Indexed as

Beta RhythmTrisomyAdolescentChildChromosome AberrationsChromosomes, Human, Pair 15ElectroencephalographyFemaleHumansIntellectual DisabilityMalePhenotypeReceptors, GABA-ASeverity of Illness IndexUbiquitin-Protein LigasesReceptors, GABA-AUBE3A protein, humanUbiquitin-Protein Ligases

Identifiers

PMID42297774
PMCPMC13493879

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.