ArticleSignal transduction and targeted therapy2026
Targeting the senescence‒autophagy axis via p16
Article in Signal transduction and targeted therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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17 authors.
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Abstract
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease for which effective therapies are lacking. While cellular senescence and autophagy have been implicated in IPF pathogenesis, the intersecting mechanisms that drive fibrosis progression remain unclear. Our patient-derived transcriptomic analysis revealed a strong association between enhanced extracellular matrix remodeling, cellular senescence, and autophagic dysfunction in IPF. Among the potential driver genes associated with cellular senescence, the elevated expression of p16
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