Evidence map›Paper›PMID 42297768›Full record

ArticleCell death & disease2026

Necroptosis is a key contributor to impaired cardiac repair following myocardial infarction.

Razoan Al Rimon, Yingxi Li, Ilamaran Meganathan, Faqi Wang, Allan G Murray, Gavin Y Oudit, Slava Epelman, Xavier Clemente-Casares, Zamaneh Kassiri

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Razoan Al RimonDepartment of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Yingxi LiDepartment of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Ilamaran MeganathanDepartment of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Faqi WangDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Allan G MurrayDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Gavin Y OuditDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0002-9154-9028
Slava EpelmanDepartment of Immunology, University of Toronto, Ted Rogers Centre for Heart Failure Research, Peter Munk Cardiac Centre, Toronto, ON, Canada.ORCID http://orcid.org/0000-0003-3400-4475
Xavier Clemente-CasaresDepartment of Medical Microbiology and Immunology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Zamaneh KassiriDepartment of Physiology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. z.kassiri@ualberta.ca.ORCID http://orcid.org/0000-0002-9357-0912

Funding

Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-469620Heart and Stroke Foundation of Canada (Heart and Stroke Foundation) G-22-0032063
6 · The paper itself

Abstract

Myocardial infarction (MI) is a leading cause of morbidity and death worldwide. Endothelial cells (ECs) contribute to post-MI remodeling through angiogenesis, inflammation, and endothelial-to-mesenchymal transition (EndMT). ADAM17, a membrane-bound protease, is upregulated in ischemic heart disease, but its role in endothelial function post-MI is unknown. We investigated whether loss of endothelial ADAM17 could improve post-MI recovery using male and female mice with inducible endothelial-specific ADAM17 knockdown (Adam17

Indexed as

ADAM17 ProteinMyocardial InfarctionNecroptosisAnimalsEndothelial CellsEndothelial-Mesenchymal TransitionFemaleHumansMaleMiceMice, Inbred C57BLMyocardiumADAM17 ProteinAdam17 protein, mouse

Identifiers

PMID42297768
PMCPMC13500855

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.