Evidence map›Paper›PMID 42297728›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2026

[Preparation of retinoic acid and irinotecan co-loaded lipo-somes and their

Shixu Lyu, Yili Zhou, Yi Xu, Fan Yang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shixu LyuDepartment of Thyroid Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, Zhejiang Province, China. 1059647116@qq.com.
Yili ZhouDepartment of Thyroid Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, Zhejiang Province, China.
Yi XuDepartment of Pharmacy, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, Zhejiang Province, China.
Fan YangDepartment of Thyroid Surgery, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, Zhejiang Province, China. wmuyangfan@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo prepare retinoic acid (RA) and irinotecan (IRI) co‑loaded liposomes (RA-IRI@Lip) and evaluate their

methodsRA-IRI@Lip was obtained through the co-encapsulation of RA and IRI within liposomes, using the thin-film hydration method. The particle size, Zeta potential, encapsulation efficiency, and

resultsThe prepared RA-IRI@Lip had an average particle size of (210.3±5.2) nm, a polydispersity index less than 0.3, and Zeta potential of －(13.7±2.3) mV. The encapsulation efficiencies of RA and IRI were (88.1±2.9)% and (86.8±1.6)%, respectively.

conclusionsRA-IRI@Lip was successfully prepared, achieving synergistic effects of differentiation therapy and chemotherapy of RA and IRI, thereby effectively eliminating ATC cells and CSCs.

Indexed as

Thyroid Carcinoma, AnaplasticThyroid NeoplasmsTretinoinCell Line, TumorHumansIrinotecanLiposomesNeoplastic Stem CellsIrinotecanLiposomesTretinoinAnaplastic thyroid carcinomaCancer stem cellsIrinotecanLiposomesRetinoic acid

Identifiers

PMID42297728
PMCPMC13388238

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.