ArticleThe Journal of international medical research2026
Association between remnant cholesterol level and gout in US adults.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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3 authors.
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Abstract
BackgroundGout is a common metabolic condition defined by high levels of uric acid in the blood and is linked to notable comorbidities. Despite extensive research on lipid metabolism and gout, the relationship between levels of remnant cholesterol, a non-traditional lipid marker, and gout remains unexplored.MethodsIn this cross-sectional analysis, a total of 11,685 adults aged ≥20 years were selected from the National Health and Nutrition Examination Survey datasets spanning 2007 to 2018. To investigate the link between remnant cholesterol level and gout, multivariate logistic regression models were employed, adjusting for demographic, lifestyle, and health-related covariates. Dose-response associations were examined using restricted cubic spline analysis, and subgroup analyses were performed to examine potential effect modifiers. In addition, mediation analyses were conducted to assess whether body mass index and serum uric acid levels partially mediated the observed association.ResultsElevated remnant cholesterol levels showed a significant relationship with a higher prevalence of gout (odds ratio = 1.01, 95% confidence interval: 1.01-1.02, per 1-mg/dL increase in remnant cholesterol level). Participants in the top quartile of remnant cholesterol level had 65% greater odds of gout than those in the bottom quartile (odds ratio = 1.65, 95% confidence interval: 1.24-2.19,
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