Evidence map›Paper›PMID 42296970›Full record

ArticleCell reports methods2026

Direct quantification of the metabolic heat output of individual Drosophila brains.

Kanishka Panda, Rohith Mittapally, Qianqian Chen, Akshay Manoj Bhaskaran, Pramod Reddy, Edgar Meyhofer, Swathi Yadlapalli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Exposure to perfluorooctanoic acid acceleratesbioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Kanishka PandaDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.
Rohith MittapallyDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.
Qianqian ChenCell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
Akshay Manoj BhaskaranDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.
Pramod ReddyDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI, USA; Department of Materials Science and Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: pramodr@umich.edu.
Edgar MeyhoferDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: meyhofer@umich.edu.
Swathi YadlapalliCell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. Electronic address: swathi@umich.edu.

Funding

Spatiotemporal mechanisms controlling circadian rhythmsR35GM133737 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Swathi Yadlapalli · 2019 to 2026
$3.4M
NIGMS NIH HHS R35 GM133737
6 · The paper itself

Abstract

Quantitative insights into brain metabolism are essential for advancing our understanding of the energy dynamics in the brain. Here, we present a nanowatt-resolution biocalorimeter capable of real-time metabolic heat output measurements of individual, live Drosophila melanogaster brains. Using this platform, we show that female brains, across multiple genotypes, exhibit a significantly higher metabolic rate (∼10%-15%) than male brains at a young age (<10 days old) and follow distinct metabolic trajectories across the lifespan. We also find that parkin mutants, a genetic model for Parkinson's disease, exhibit a ∼15% reduction in brain metabolic output relative to controls, revealing that defective mitophagy due to parkin deficiency affects brain metabolism. Further, we demonstrate that the metabolic output of a Drosophila brain is ∼2.5-fold higher than reproductive tissues like ovary and testis. Together, these advances open new avenues for investigating the impact of aging, neurodegeneration, and disease states on brain metabolism.

Indexed as

BrainDrosophila melanogasterAgingAnimalsDrosophila ProteinsEnergy MetabolismFemaleHot TemperatureMaleUbiquitin-Protein LigasesDrosophila Proteinspark protein, DrosophilaUbiquitin-Protein LigasesagingbiocalorimetrybrainCP: metabolismDrosophilametabolismneurodegeneration

Identifiers

PMID42296970
PMCPMC13494548

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.