Integration of Federated Learning and Blockchain in Health Care: Tutorial on Medical Data, Architectures, Privacy, Security, and Regulatory Compliance.

Unlabelled: The convergence of artificial intelligence (AI), blockchain technology, and health care represents one of the most transformative yet technically challenging frontiers in computational medicine. As health care systems adopt data-driven paradigms for precision medicine and clinical decision support, the need for secure, privacy-preserving, and collaborative learning frameworks has become critical. This tutorial introduces a comprehensive, clinically oriented, and compliance-aware framework integrating federated learning (FL) and blockchain for secure and privacy-preserving health care analytics. FL enables collaborative training across distributed institutions without raw data sharing, in alignment with privacy regulations such as the Health Insurance Portability and Accountability Act (HIPAA) and the General Data Protection Regulation (GDPR). However, FL remains vulnerable to model poisoning and gradient leakage. To address these risks, we introduce blockchain-based FL (BCFL), which leverages blockchain's immutable ledger and decentralized consensus to enhance trust, verifiability, and auditability. The tutorial's main contributions include (1) a taxonomy of diverse medical data types and their FL requirements; (2) three integration architectures (fully coupled, semicoupled, and loosely coupled) analyzed for security, scalability, and regulatory compliance; (3) a security analysis of health care-specific vulnerabilities and mitigation strategies using advanced cryptography, such as zero-knowledge proofs, homomorphic encryption, and differential privacy; and (4) a regulatory compliance framework addressing HIPAA, GDPR, and United States Food and Drug Administration guidelines for AI-enabled medical devices. We demonstrate BCFL's relevance across major health care applications, including disease prediction, medical imaging, patient monitoring, and drug discovery, and highlight emerging research directions such as quantum-resilient cryptography, scalable interoperability, and automated compliance. This tutorial serves as a foundational resource for advancing secure, compliant, and collaborative AI in health care; fostering privacy-preserving analytics; and improving patient outcomes.