Evidence map›Paper›PMID 42296432›Full record

ArticleChemistry & biodiversity2026

Rosa rubiginosa L. Extract Rich in Bioactive Phenolics Possess Potent Anti-Inflammatory, Antioxidant, Photoprotective, and Antimicrobial Biofunctional Activities.

Sophia Letsiou, Konstantina Kyratzi, Aliki Tsakni, Dimitrios Kranas, Konstantinos Pavlidis, Anna Ofrydopoulou, Panagiotis Halvatsiotis, Dimitra Houhoula, Alexandros Tsoupras

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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sophia LetsiouDepartment of Food Science and Technology, University of West Attica, Athens, Greece.ORCID https://orcid.org/0000-0002-9155-0889
Konstantina KyratziHephaestus Laboratory, School of Chemistry, Faculty of Sciences, Democritus University of Thrace, Kavala, Greece.
Aliki TsakniDepartment of Food Science and Technology, University of West Attica, Athens, Greece.
Dimitrios KranasHephaestus Laboratory, School of Chemistry, Faculty of Sciences, Democritus University of Thrace, Kavala, Greece.
Konstantinos PavlidisHephaestus Laboratory, School of Chemistry, Faculty of Sciences, Democritus University of Thrace, Kavala, Greece.
Anna OfrydopoulouHephaestus Laboratory, School of Chemistry, Faculty of Sciences, Democritus University of Thrace, Kavala, Greece.ORCID https://orcid.org/0000-0003-3925-6284
Panagiotis Halvatsiotis2nd Propaedeutic Department of Internal Medicine, Medical School, "ATTIKON" University Hospital, National and Kapodistrian University of Athens, Chaidari, Greece.
Dimitra HouhoulaDepartment of Food Science and Technology, University of West Attica, Athens, Greece.
Alexandros TsouprasHephaestus Laboratory, School of Chemistry, Faculty of Sciences, Democritus University of Thrace, Kavala, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hydroethanolic Rosa rubiginosa extract is evaluated in vitro for antioxidant, anti-inflammatory, antiplatelet, photoprotective, and antimicrobial activities. Rich in phenolics and carotenoids, it shows strong antioxidant activity (notably in DPPH) and high SPF-related UV protection. Major compounds include rosmarinic acid, hydroxybenzoic acid, quercetin, and luteolin. Synergistic interactions among bioactives enhance antioxidant capacity beyond that of individual compounds. The extract demonstrates pronounced anti-inflammatory effects against platelet-activating factor (PAF), exceeding those of isolated standards, while showing lower activity against ADP-induced platelet aggregation, indicating specificity toward PAF-mediated pathways. Molecular docking supports interactions with the PAF receptor. Given PAF's role in UV-induced inflammation and melanoma, the extract's UV absorption, antioxidant capacity, and anti-PAF activity suggest protective effects against photoaging. Antimicrobial activity is stronger against Gram-negative bacteria, with slower effects on Gram-positive strains. Overall, R. rubiginosa extract exhibits broad bioactivity, supporting its potential as a multifunctional ingredient in functional foods, nutraceuticals, supplements, and cosmetic formulations.

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalAntioxidantsPhenolsPlant ExtractsRadiation-Protective AgentsRosaBiphenyl CompoundsGram-Negative BacteriaGram-Positive BacteriaHumansMicrobial Sensitivity TestsMolecular Docking SimulationPicratesAnti-Bacterial AgentsAnti-Infective AgentsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalAntioxidantsBiphenyl CompoundsPhenolsPicratesPlant Extractsplatelet activating factor receptorPlatelet Membrane GlycoproteinsRadiation-Protective AgentsReceptors, G-Protein-Coupledanti‐inflammatoryantimicrobialantioxidantcarotenoidsPAF inhibitionPAF receptorphotoprotectiveRosa rubiginosa L

Identifiers

PMID42296432
PMCPMC13268575

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.