Evidence map›Paper›PMID 42296419›Full record

ArticleChemistry & biodiversity2026

Monoamine Oxidase and Cholinesterase Inhibition Profiles of Semicarbazone and Thiosemicarbazone Derivatives.

Sandeep Bindra, Won Kyeong Jeong, Muzammil Kabier, Sunil Kumar, Sachithra Thazhathuveedu Sudevan, Harish Chandra Vishwakarma, Della Grace Thomas Parambi, Naseer Maliyakkal, Sandeep Kumar, Leena K Pappachen and 2 more

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sandeep BindraDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, India.
Won Kyeong JeongDepartment of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, South Korea.
Muzammil KabierDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, India.
Sunil KumarDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, India.
Sachithra Thazhathuveedu SudevanDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, India.
Harish Chandra VishwakarmaDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, India.
Della Grace Thomas ParambiDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Aljouf, Saudi Arabia.
Naseer MaliyakkalDepartment of Basic Medical Sciences, College of Applied Medical Sciences, King Khalid University, Khamis Mushait, Saudi Arabia.
Sandeep KumarSchool of Pharmacy & DST-FIST, Sharda University, Greater Noida, Uttar Pradesh, India.
Leena K PappachenDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, India.
Hoon KimDepartment of Pharmacy, College of Pharmacy, Sunchon National University, Suncheon, South Korea.
Bijo MathewDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, AIMS Health Sciences Campus, Amrita Vishwa Vidyapeetham, Kochi, India.

Funding

Deanship of Research and Graduate Studies at King Khalid University RGP2/330/47Korean Government RS-2024-00347522National Research Foundation of Korea (NRF)
6 · The paper itself

Abstract

Twenty semicarbazone and thiosemicarbazone derivatives (T1-T20) were synthesized and evaluated for their inhibition of monoamine oxidases and cholinesterases. Most compounds showed stronger inhibition of MAO-B than MAO-A. Among the synthesized compounds, T6 most strongly inhibited MAO-B (IC

Indexed as

Cholinesterase InhibitorsMonoamine OxidaseMonoamine Oxidase InhibitorsSemicarbazonesThiosemicarbazonesAcetylcholinesteraseAnimalsButyrylcholinesteraseDose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsMonoamine OxidaseMonoamine Oxidase InhibitorsSemicarbazonesThiosemicarbazonesbutyrylcholinesterasemonoamine oxidase‐BMzDOCKsemicarbazonesstructure–activity relationshipsthiosemicarbazones

Identifiers

PMID42296419
PMCPMC13268573

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.