ArticleJournal of surgical oncology2026
Classification of High- and Low-Risk Patients With Dermal Leiomyosarcoma: An Exploratory Nationwide Cohort Study.
Article in Journal of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Classification of High- and Low-Risk Patients With Dermal Leiomyosarcoma: An Exploratory Nationwide Cohort Study.Journal of surgical oncology · 2026Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundRisk factors for dermal leiomyosarcoma (dLMS) metastasis remain poorly defined because methodological constraints, small sample sizes, and short follow-up have limited previous studies.
objectivesTo investigate risk factors for metastasis and local recurrence, and to propose a high- and low-risk classification for dLMS.
methodsAll patients diagnosed with dLMS in Denmark between 1980 and 2022 were included. Absolute 5‑year risks were estimated using the Aalen-Johansen method, treating all‑cause mortality as a competing risk.
resultsAmong 381 patients (median age 66 years, 71% male), the 5-year risk of metastasis was 2.4% and 10% for local recurrence. The most important risk factors for metastasis were tumor necrosis, mitotic grade 3, and perineural/intravascular invasion, with 5-year absolute risks ranging between 9% and 25%. Positive surgical margins and perineural/intravascular invasion were associated with increased 5-year absolute risks of local recurrence, ranging between 26% and 50%.
conclusionAlthough few distant metastases were observed, high-risk dLMS features may include tumor necrosis, mitotic grade 3, perineural/intravascular invasion, or positive surgical margins. Cases without these features may be classified as low-risk dLMS. We propose regular cross-sectional imaging in the follow-up of patients with high-risk dLMS, whereas follow-up for patients with low-risk dLMS could be limited to clinical examinations.
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