Evidence map›Paper›PMID 42296364›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Tuning reductase activity in monoterpene indole alkaloid biosynthesis.

Samuel C Carr, Song Wu, Klaus Gase, Yoko Nakamura, Mohamed O Kamileen, Maritta Kunert, Sarah Heinicke, Moonyoung Kang, Veit Grabe, Lorenzo Caputi and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Samuel C CarrDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena 07745, Germany.ORCID 0000-0001-7060-5038
Song WuDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena 07745, Germany.
Klaus GaseDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena 07745, Germany.ORCID 0000-0002-8028-5645
Yoko NakamuraDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena 07745, Germany.ORCID 0000-0002-9622-1005
Mohamed O KamileenDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena 07745, Germany.ORCID 0000-0002-1346-1055
Maritta KunertDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena 07745, Germany.ORCID 0009-0007-5848-4262
Sarah HeinickeDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena 07745, Germany.
Moonyoung KangDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena 07745, Germany.ORCID 0000-0002-4630-4312
Veit GrabeMicroscopic Imaging Service Group, Max Planck Institute for Chemical Ecology, Jena 07745, Germany.
Lorenzo CaputiDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena 07745, Germany.ORCID 0000-0002-7783-6733
Sarah E O'ConnorDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena 07745, Germany.ORCID 0000-0003-0356-6213

Funding

Max Planck Society NA
6 · The paper itself

Abstract

Monoterpene indole alkaloids encompass a diverse class of plant natural products. Many of these valuable compounds, including the anticancer medicines vinblastine and vincristine (

Indexed as

Indole AlkaloidsMonoterpenesOxidoreductasesPlant ProteinsCatharanthusIndole AlkaloidsMonoterpenesOxidoreductasesPlant Proteinsalkaloidsbiosynthesisgeissoschizineheterodimernatural products

Identifiers

PMID42296364
PMCPMC13291617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.