ReviewJournal of visualized experiments : JoVE2026
The Mammalian Ocular Lens in Focus: Development, Anatomy, Physiology, Transparency, Biomechanics, and Age-related Challenges.
Review in Journal of visualized experiments : JoVE, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Global challenges for lens and cataract research.Frontiers in ophthalmology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The lens is a transparent, ellipsoid organ in the anterior chamber of the eye that focuses light onto the retina. Composed of epithelial cells and fiber cells, this 3-dimensional tissue is highly organized to ensure a clear light path and utilizes multiple strategies to establish and maintain a high refractive index and transparency. In humans, the lens undergoes shape changes to focus light from different distances in a process known as accommodation, and these elastic and biomechanical properties of the lens rely on tissue, cellular, and molecular mechanisms. Cataracts, defined as any opacity in the normally transparent lens, remain the leading cause of blindness in the world. Presbyopia, due to age-related changes in lens stiffness, has been linked to accommodative decline and the need for reading glasses. This review will explore mammalian lens development and lifelong growth, crystallins and cytoskeletal proteins, cell-cell communication and microcirculation, lens biomechanics, and the challenges and novel methods for studying this unique tissue.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.