ArticlePlant physiology2026
GhCOR27 confers Verticillium wilt resistance in cotton by relieving the GhASIL1-GhERF114-mediated repression of lignin accumulation.
Article in Plant physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Verticillium wilt (VW) severely limits cotton production; yet, the molecular mechanisms underlying cotton immunity remain incompletely understood. Here, comparative transcriptomic analyses of resistant and susceptible cotton germplasms identified the cold-regulated gene GhCOR27 as a positive regulator of VW resistance. GhCOR27 expression was consistently induced by Verticillium dahliae infection in both resistant and susceptible materials. Functional validation showed that silencing GhCOR27 enhanced susceptibility, whereas its overexpression in cotton and Arabidopsis markedly improved VW resistance. Through yeast 2-hybrid (Y2H), bimolecular fluorescence complementation (BiFC), luciferase complementation (LCI), co-immunoprecipitation (Co-IP), and GST pull-down, we further demonstrated that GhCOR27 directly interacts with the trihelix transcription factor GhASIL1. Silencing and overexpression in Arabidopsis revealed GhASIL1 acts as a negative regulator of VW resistance. Transcriptome profiling indicated that GhCOR27 and GhASIL1 coregulate the phenylpropanoid pathway, lignin accumulation, and ROS/NO signaling during defense. Mechanistically, DNA affinity purification sequencing (DAP-seq), yeast one-hybrid (Y1H), dual-luciferase (LUC), and electrophoretic mobility shift assay (EMSA) assays revealed that GhASIL1 directly binds the GT-box cis-element in the promoter of GhERF114, a defense-related transcription factor, and represses its expression. Importantly, GhCOR27 antagonizes GhASIL1-mediated repression of GhERF114 without binding to the GhERF114 promoter itself. Subsequently, GhERF114 activates the expression of the lignin biosynthetic gene GhHCT1, thereby promoting lignification and strengthening disease resistance. Together, we conclude that GhCOR27 confers VW resistance in cotton by relieving the GhASIL1-GhERF114-mediated repression of lignin accumulation, which provide a new insight into the molecular mechanisms of cotton defense against VW.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.