ArticleClinical cardiology2026
Sedentary Behavior, Physical Activity, and Hypertension: Genetic Liability and the Role of Metabolic Factors.
Article in Clinical cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Sedentary Behavior, Physical Activity, and Hypertension: Genetic Liability and the Role of Metabolic Factors.Clinical cardiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhether sedentary behavior and physical activity causally influence hypertension remains uncertain. We used Mendelian randomization (MR) to examine whether genetically predicted domain-specific sedentary behaviors and leisure-time physical activity are associated with hypertension risk and to explore potential cardiometabolic pathways.
methodsWe performed a two-sample MR using genome-wide significant, LD-independent SNPs as instruments for domain-specific sedentary traits and physical activity. Hypertension was defined by the FinnGen R9 endpoint I9_HYPTENSESS. Pleiotropy-robust estimators, outlier procedures and two-step MR mediation analyses were applied.
resultsGenetically proxied leisure screen time (LST) was associated with a higher risk of hypertension (IVW OR = 1.181, 95% CI 1.076-1.296, p = 4.70e
conclusionGenetically proxied LST was associated with higher hypertension risk and may represent a plausible, potentially actionable prevention target. BMI and T2D may partly account for this association. No robust associations were observed for MVPA or SDW, but these null findings should not be interpreted as definitive evidence of no effect. Further validation in prospective, multi-ancestry, and mechanistic studies is needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.