Evidence map›Paper›PMID 42296005›Full record

ArticleCell biology international2026

Temporal Lysophosphatidic Acid Supplementation Enhances Megakaryocyte Differentiation and Platelet Production From Human Hematopoietic Progenitors.

Nittaya Jiamvoraphong, Chanchao Lorthongpanich, Praphasri Septham, Phatchanat Klaihmon, Pakpoom Kheolamai, Chuti Laowtammathron, Sumeth Imsoonthornruksa, Mariena Ketudat-Cairns, Surapol Issaragrisil

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Article in Cell biology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nittaya JiamvoraphongSiriraj Center of Excellence for Stem Cell Research, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Chanchao LorthongpanichSiriraj Center of Excellence for Stem Cell Research, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.ORCID https://orcid.org/0000-0003-2206-7065
Praphasri SepthamSiriraj Center of Excellence for Stem Cell Research, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Phatchanat KlaihmonSiriraj Center of Excellence for Stem Cell Research, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Pakpoom KheolamaiCenter of Excellence in Stem Cell Research and Innovation, Faculty of Medicine, Thammasat University, Pathumthani, Thailand.
Chuti LaowtammathronSiriraj Center of Excellence for Stem Cell Research, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Sumeth ImsoonthornruksaCenter for Biomolecular Structure Function and Application, School of Biotechnology, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Mariena Ketudat-CairnsCenter for Biomolecular Structure Function and Application, School of Biotechnology, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Surapol IssaragrisilSiriraj Center of Excellence for Stem Cell Research, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Funding

Mahidol Univeristy Fundamental FundMahidol Univeristy R016841007Mahidol Univeristy R016941010
6 · The paper itself

Abstract

Platelet shortages and limited storage stability restrict global platelet transfusion capacity, highlighting the need for efficient in vitro platelet production systems. This study establishes a simple, non-genetic and cost-effective system for efficient in vitro platelet-like particle (PLP) production from human hematopoietic stem/progenitor cells (HSPCs) using a Phase-specific modulation of Hippo-YAP/TAZ signaling modulation. Temporal control of Hippo-YAP/TAZ signaling by lysophosphatidic acid (LPA), an activator of YAP/TAZ activity, significantly enhanced megakaryocyte differentiation, expansion and PLP production, resulting in an approximately 15-fold increase in PLP yield at the end of the procedure. Furthermore, LPA extended the expansion period of HSPC-derived megakaryocytes up to 8 days, resulting in a greater than 20-fold increase in the number of HSPC-derived CD41

Indexed as

Blood PlateletsHematopoietic Stem CellsLysophospholipidsMegakaryocytesCell DifferentiationCells, CulturedHumansSignal TransductionThrombopoiesisThrombopoietinlysophosphatidic acidLysophospholipidsThrombopoietinhematopoietic celllysophosphatidic acidmegakaryocyteplateletTPO

Identifiers

PMID42296005
PMCPMC13268131

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.