Evidence map›Paper›PMID 42295942›Full record

ArticleJournal of magnetic resonance imaging : JMRI2026

Free-Breathing Dynamic, Regularized, Adaptive Cluster Optimization (DRACO) Cine Cardiac MRI in Atrial Fibrillation.

Zhengyang Ming, Arutyun Pogosyan, Xinyu Dong, J Paul Finn, Dan Ruan, Anthony G Christodoulou, Kim-Lien Nguyen

Abstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhengyang MingPhysics and Biology in Medicine Graduate Program, University of California, Los Angeles, California, USA.
Arutyun PogosyanDivision of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Xinyu DongDivision of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.ORCID https://orcid.org/0009-0007-2021-8057
J Paul FinnPhysics and Biology in Medicine Graduate Program, University of California, Los Angeles, California, USA.
Dan RuanPhysics and Biology in Medicine Graduate Program, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-3400-7684
Anthony G ChristodoulouPhysics and Biology in Medicine Graduate Program, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-9334-8684
Kim-Lien NguyenPhysics and Biology in Medicine Graduate Program, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-8854-2976

Funding

Expanding on a new paradigm for MRI in pediatric congenital heart diseaseR01HL127153 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTODOULOU, ANTHONY G, FINN, JOHN PAUL · 2015 to 2024
$6.1M
Ferumoxytol-Enhanced Cardiac MRI for Ischemic Heart DiseaseR01HL148182 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NGUYEN, KIM-LIEN T · 2020 to 2024
$3.8M
CSRD VA I01 CX001901NHLBI NIH HHS R01 HL127153NHLBI NIH HHS R01 HL148182NIH HHS R01HL127153NIH HHS R01HL148182Veterans Administration Medical Center I01CX001901
6 · The paper itself

Abstract

backgroundExisting strategies for free-breathing cine cardiac MR, including real-time imaging, struggle with complex arrhythmias such as atrial fibrillation (AF). Dynamic regularized adaptive clustering optimization (DRACO) has been proposed to generate high-quality and quantifiable breath-held cine images for patients in AF. PURPOSE: To tailor DRACO for free-breathing and evaluate its potential to simultaneously handle cardiac and respiratory motion. STUDY TYPE: Prospective. SUBJECTS: 10 sinus rhythm (10 males), 20 AF (18 males). FIELD STRENGTH/SEQUENCE: 3.0 T, balanced steady-state free precession (bSSFP) with sorted golden-step, ECG-gated segmented cine, and real-time. ASSESSMENT: Patients were imaged using the golden-step sequence under breath-held and free-breathing conditions, and the reference bSSFP cine sequence. Signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), edge sharpness, and image quality (4-point Likert scale) were assessed. STATISTICAL TESTS: Paired t-test, Friedman test, regression analysis, Fleiss' Kappa. Significance level p < 0.05.

resultsThe SNR and CNR values of DRACO images showed no significant differences between breath-held and free-breathing conditions in both sinus rhythm (SNR p = 0.53; CNR p = 0.87) and in AF (SNR p = 0.56; CNR p = 0.55). Image sharpness was not significantly different between breath-held and free-breathing in both sinus rhythm (p = 0.24) and AF (p = 0.79). In AF patients, breath-held DRACO and free-breathing DRACO had significantly higher image quality scores than real-time cine. In sinus rhythm patients, there was no significant difference (p = 0.13) between breath-held or free-breathing DRACO and segmented cine. Despite significant within-patient ejection fraction (EF) differences between breath-held versus free-breathing in 80% of sinus rhythm and 70% of AF patients, the average EF between breath-held versus free-breathing DRACO showed high correlation (sinus rhythm R DATA

conclusionDRACO is robust to respiratory motion and AF-related irregular cardiac motion. It enables high-quality cine image generation in both regular and irregular cardiac motion, with or without breath holding. LEVEL OF EVIDENCE: 1: TECHNICAL EFFICACY: Stage 2.

Indexed as

Atrial FibrillationHeartImage Processing, Computer-AssistedMagnetic Resonance Imaging, CineAgedAlgorithmsBreath HoldingCluster AnalysisClustering AlgorithmsElectrocardiographyFemaleHumansImage Interpretation, Computer-AssistedMaleMiddle AgedMotionatrial fibrillationcardiac motionclustering algorithmfree breathinggolden‐step acquisitionrespiration motionself‐gating

Identifiers

PMID42295942
PMCPMC13466586

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.