SynthesisThe Indian journal of medical research2026
Burden of scrub typhus in north-eastern region of India: A systematic review and meta-regression analysis.
Synthesis in The Indian journal of medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and objectives Scrub typhus is endemic in India and neighbouring countries. India's north-eastern region (NER) is geographically and ecologically distinct from the rest of the country, with variations in climate, ecology, land use patterns, and population behaviours, heightening the risk of scrub typhus among the residents. Scrub typhus remains an under-explored zoonotic disease in the region. Methods A systematic review was conducted to estimate the burden of scrub typhus in the NER of India. Six databases were searched for studies on the prevalence, seroprevalence, and case fatality rate of scrub typhus in NER. A meta-regression analysis was conducted to ascertain the sources of heterogeneity. Results A total of 718 studies were retrieved from the included databases. Twelve hospital-based prevalence studies spanning 7 States and 4 community-based seroprevalence studies spanning 5 States met the eligibility criteria. The prevalence of scrub typhus among patients with febrile illness and/or clinically suspected cases ranged from 7-36%, while seroprevalence among healthy individuals ranged from 0.8-45%; the case fatality rate ranged from 3-13%. Multivariable meta-regression identified region (P=0.004) and sample size (P=0.003) as significant moderators for prevalence, but not for seroprevalence. Interpretation and conclusions This review highlights the under-recognised burden of scrub typhus in the NER of India. Studies, though limited, underscore the need for better epidemiological data, enhanced surveillance, and community-based research, particularly in high-risk areas.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.