Evidence map›Paper›PMID 42295705›Full record

SynthesisBiological trace element research2026

Environmental Burden of Lead and Public Health Issues in Nigeria: A Systematic Review of Emerging Evidence.

Polycarp Dauda Madaki, Chiara Frazzoli, James Owupele Ibibama, Anthony Saah Tengbeh, Orish E Orisakwe

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Biological trace element research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Polycarp Dauda MadakiAfrican Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB 5323, Choba, Port Harcourt, Nigeria.ORCID http://orcid.org/0009-0001-8216-9779
Chiara FrazzoliDepartment of Cardiovascular, Endocrine-Metabolic Diseases, and Aging, Istituto Superiore di Sanità, Rome, 00162, Italy.
James Owupele IbibamaDepartment of Experimental Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Port-Harcourt, Port Harcourt, Nigeria.
Anthony Saah TengbehAfrican Centre of Excellence for Public Health and Toxicological Research (ACE-PUTOR), University of Port Harcourt, PMB 5323, Choba, Port Harcourt, Nigeria.
Orish E OrisakweAdvanced Research Centre, European University of Lefke, TR-10 Mersin, Lefke, Northern Cyprus, Turkey. orishebere@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLead exposure remains a critical global health liability, with Nigeria facing unique challenges driven by artisanal mining and informal industrial activities. This systematic review consolidates evidence on lead's environmental burden, human exposure pathways, and multi-system health outcomes in Nigeria to support the 2025-2030 elimination agenda.

methodsFollowing PRISMA guidelines, we searched Scopus, Web of Science, PubMed, and Google Scholar for studies published up to March 2026. Eligibility focused on lead contamination in Nigerian human populations and environmental media (soil, water, air, food).

resultsTwenty-seven studies (2004-2026) were included. Findings reveal extreme soil (up to 185,000 ppm) and water (179x WHO limits) contamination in northern artisanal mining zones, notably the 2010 Zamfara outbreak which caused 400-500 child deaths. In urban centers, 70-100% of occupationally exposed artisans (mechanics, battery technicians) exhibit blood lead levels (BLL) ≥ 5 µg/dL. Documented health consequences span neurological (encephalopathy, convulsions), renal (chronic kidney disease staging), hematological (anemia), endocrine (thyroid dysfunction), and cardiovascular systems.

conclusionLead exposure in Nigeria is a chronic, multi-dimensional crisis. While acute mortality is concentrated in mining regions, diffuse contamination of food chains and urban dust poses widespread risks. Addressing this requires strengthening the 2025 national strategic plan through enhanced BLL surveillance, enforcement of lead-paint bans, and formalizing the informal industrial sector.

Indexed as

Environmental ExposureLeadLead PoisoningPublic HealthHumansMiningNigeriaLeadArtisanal miningEnvironmental healthLead poisoningNigeriaOne healthSystematic review

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.