Evidence map›Paper›PMID 42295701›Full record

ArticleDrug delivery and translational research2026

Transdermal delivery and anti-inflammatory efficacy of Mitragyna speciosa extract transdermal patch for local inflammation management: in vitro, ex vivo, and in vivo investigations.

Sarunya Tuntiyasawasdikul, Jintana Junlatat, Peera Tabboon, Ekapol Limpongsa, Napaphak Jaipakdee

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Article in Drug delivery and translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sarunya TuntiyasawasdikulFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand.ORCID http://orcid.org/0009-0004-9370-736X
Jintana JunlatatFaculty of Thai Traditional and Alternative Medicine, Ubon Ratchathani Rajabhat University, Ubon Ratchathani, 34000, Thailand.ORCID http://orcid.org/0009-0000-4067-5799
Peera TabboonFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand.ORCID http://orcid.org/0009-0004-7577-2408
Ekapol LimpongsaCollege of Pharmacy, Rangsit University, Pathum Thani, 12000, Thailand.ORCID http://orcid.org/0000-0002-6198-4029
Napaphak JaipakdeeFaculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40002, Thailand. jsaowanee@kku.ac.th.ORCID http://orcid.org/0000-0002-8338-3590

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to fabricate and characterize a polymeric matrix-type transdermal patch containing Mitragyna speciosa ethanolic extract (MSE) using an Eudragit RL100/polyvinylpyrrolidone (ERL/PVP) matrix. Eight different MSE polymeric matrices with varying ERL/PVP ratios, solvent-type permeation enhancers, and MSE loadings were successfully prepared using the solvent casting technique. All polymeric matrices had average thickness of 272.5-316.0 μm with mitragynine content of 198.45-280.86 µg/cm². ATR-FTIR indicated a lack of intermolecular interactions between MSE and ERL or PVP. Mitragynine release followed a square root of time dependence, with a rate of 12.74-17.72 µg/cm

Indexed as

Anti-inflammatory patchEudragit RL100/PVP matrixHerbal extract patchMitragyninePermeation enhancersTransdermal patch

Identifiers

PMID42295701

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.