Evidence map›Paper›PMID 42295620›Full record

ArticleBrain tumor pathology2026

Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype, of the adult cerebellum: a report of 2 cases.

Kaishi Satomi, Yukino Nikai, Kuniaki Saito, Miho Gomyo, Kazuhiro Tsuchiya, Kiyotaka Nagahama, Nobuyoshi Sasaki, Keiichi Kobayashi, Yoji Tanaka, Motoo Nagane and 1 more

Abstract read
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Article in Brain tumor pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kaishi SatomiDepartment of Pathology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Yukino NikaiDepartment of Pathology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Kuniaki SaitoDepartment of Neurosurgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Miho GomyoDepartment of Radiology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Kazuhiro TsuchiyaDepartment of Radiology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Kiyotaka NagahamaDepartment of Pathology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Nobuyoshi SasakiDepartment of Neurosurgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Keiichi KobayashiDepartment of Neurosurgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Yoji TanakaDepartment of Neurosurgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Motoo NaganeDepartment of Neurosurgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan.
Junji ShibaharaDepartment of Pathology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan. jshiba@ks.kyorin-u.ac.jp.ORCID http://orcid.org/0000-0002-8449-7039

Funding

JSPS KAKENHI 22K06951JSPS KAKENHI 25K10270
6 · The paper itself

Abstract

The 2021 World Health Organization (WHO) Classification of Tumors of the Central Nervous System, 5th Edition, defines diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype (dpHGG, H3-/IDH-WT) as a molecularly distinct entity, primarily diagnosed by DNA methylation profiling. Although this tumor predominantly occurs in children, its clinicopathological characteristics in adults are poorly understood. Here, we report two adult patients with cerebellar tumors that were histologically consistent with glioblastoma, but were reclassified as dpHGG, H3-/IDH-WT, RTK1 subtype based on genome-wide DNA methylation analysis. Both patients presented with large infiltrative cerebellar masses and experienced an aggressive clinical course with early postoperative progression. Histologically, the tumors exhibited high cellularity, marked cytological atypia, brisk mitotic activity, and microvascular proliferation without necrosis. Molecular analyses revealed PDGFRA amplification and homozygous deletion of CDKN2A in both cases, while neither showed EGFR amplification. These findings suggest that a subset of morphologically defined cerebellar glioblastomas in adults represents the dpHGG, H3-/IDH-WT, RTK1 subtype. Recognition of this underappreciated manifestation is important for accurate tumor classification, and further accumulation of well-characterized cases is required to clarify its clinical significance.

Indexed as

Cerebellar glioblastomaDiffuse pediatric-type high-grade gliomaDNA methylation profilingH3-wildtype and IDH-wildtypeRTK1 subtype

Identifiers

PMID42295620

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