Evidence map›Paper›PMID 42295585›Full record

ArticleApplied psychophysiology and biofeedback2026

Aerobic Exercise Rejuvenates the Fatigued Brain: Evidence from EEG and Flicker Values.

Tomomi Nomura, Kazuki Fujita, Kaori Kawabata, Nobuhiro Takahashi, Yasutaka Kobayashi

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In one paragraph

Article in Applied psychophysiology and biofeedback, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tomomi NomuraDepartment of Rehabilitation, Faculty of Health Science, Fukui Health Science University, 55-13-1 Egami-cho, Fukui City, 910-3190, Fukui, Japan. t-nomura@fukui-hsu.ac.jp.
Kazuki FujitaGraduate School of Health Science, Fukui Health Science University, Fukui City, Japan.
Kaori KawabataGraduate School of Health Science, Fukui Health Science University, Fukui City, Japan.
Nobuhiro TakahashiDepartment of Rehabilitation, Faculty of Health Science, Fukui Health Science University, 55-13-1 Egami-cho, Fukui City, 910-3190, Fukui, Japan.
Yasutaka KobayashiGraduate School of Health Science, Fukui Health Science University, Fukui City, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to examine the restorative effects of aerobic exercise on mental fatigue using physiological indicators. Mental fatigue was induced in healthy adults using the Paced Auditory Serial Addition Test. Of these, 40 participants who exhibited confirmed fatigue based on flicker values were randomly assigned to either an exercise group (20 min of aerobic exercise) or a rest group (20 min of bed rest); n = 20 per group. Flicker values and electroencephalographic (EEG) parameters (mean power of theta, alpha, and beta waves) were measured before and after the intervention. Fatigue recovery was assessed through within-group comparisons of pre- and post-intervention values and between-group comparisons of change scores. In the exercise group, flicker values significantly increased post-intervention, and this change was significantly greater than that in the rest group. EEG analysis revealed a significant increase in theta power post-intervention in the exercise group. Additionally, alpha and beta power increased significantly, with changes greater than those in the rest group. Conversely, no significant changes in flicker values or EEG measures were observed in the rest group. Correlation analysis revealed that the degree of recovery in flicker values was significantly and positively correlated with increases in alpha and beta wave power. Aerobic exercise produced a significantly greater restorative effect on mental fatigue than bed rest, as evidenced by objective indicators such as flicker values and EEG measures. The findings suggest that aerobic exercise is a promising intervention for addressing mental fatigue in contemporary society.Trial registration UMIN000057499, Registered 3 April 2025 (retrospectively registered).

Indexed as

Aerobic exerciseElectroencephalographyFlickerMental fatigue

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.