A deep learning framework for lesion-level treatment response prediction in hodgkin lymphoma using PET/CT tensor radiomics.

backgroundAccurate prediction of treatment response in Hodgkin lymphoma (HL) is crucial for personalized therapy. The Tensor Radiomics (TR) paradigm advances traditional radiomics by producing and analyzing diverse feature variations, employing tensors computed across multiple parameter combinations to optimize radiomics feature extraction and improve tumor characterization. However, the complexity and variability of these features pose significant challenges for analysis and clinical application in HL research. This study introduces the Tensor Radiomics Network (TR-NET), a deep learning framework that automates feature selection from tensor radiomics data and predicts treatment response. It also incorporates explainable AI techniques to identify the most influential features.

methodsWe analyzed 420 lesions from 70 HL patients using

resultsTR-NET achieved a predictive performance, with an AUC-ROC of 0.8470 (95% CI: 0.7669-0.9185), a sensitivity of 82.2%, and a specificity of 78.2%, offering a balanced classification characteristic. In comparison, XGBoost achieved an AUC of 0.8160 (95% CI: 0.7457-0.8599), characterized by high sensitivity (93.3%) but lower specificity (66.2%), indicating a tendency towards false positives. Random Forest and SVM also showed high sensitivity (92% and 91.1%), but both suffered from significantly reduced specificity (29.5% and 51.3%).

conclusionTR-NET demonstrates enhanced predictive accuracy and clinical relevance compared to classic machine learning, supporting personalized treatment strategies and the integration of explainable AI in oncology.