Evidence map›Paper›PMID 42295399›Full record

ArticleSurgery today2026

Prognostic impact of malnutrition based on the global leadership initiative on malnutrition criteria in older patients undergoing liver resection for hepatocellular carcinoma.

Satoshi Omiya, Takeshi Urade, Shohei Komatsu, Kenji Fukushima, Shinichi So, Toshihiko Yoshida, Keisuke Arai, Masayuki Akita, Takuya Mizumoto, Jun Ishida and 5 more

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Satoshi OmiyaDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Takeshi UradeDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan. uradet1125@gmail.com.ORCID http://orcid.org/0000-0002-4557-1777
Shohei KomatsuDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Kenji FukushimaDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Shinichi SoDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Toshihiko YoshidaDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Keisuke AraiDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Masayuki AkitaDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Takuya MizumotoDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Jun IshidaDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Yoshihide NannoDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Sadaki AsariDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Hiroaki YanagimotoDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Masahiro KidoDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.
Takumi FukumotoDepartment of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to evaluate preoperative malnutrition using the Global Leadership Initiative on Malnutrition (GLIM) criteria and determine whether its prognostic impact after initial liver resection (LR) differs between older (≥70 years) and younger (<70 years) patients with hepatocellular carcinoma (HCC).

methodsThis retrospective analysis included 330 patients with HCC who underwent LR between January 2011 and December 2019 at our institution. Overall survival (OS), recurrence-free survival (RFS), postoperative recurrence patterns, and treatment strategies for recurrence were compared between the two groups.

resultsAmong the 330 patients with HCC, 150 and 180 were classified into younger and older groups, respectively. Preoperative severe malnutrition was independently associated with OS (p=0.001) and RFS (p=0.044) in older patients and with RFS (p=0.039), but not OS, in younger patients. Moreover, in older patients, preoperative malnutrition was associated with a lower rate of aggressive treatments for intrahepatic recurrence (p=0.018) and a higher rate of extrahepatic recurrence (p=0.023) after LR, which was not observed in younger patients.

conclusionsSevere malnutrition, as per the GLIM criteria, is a significant independent predictor of OS and RFS in older patients with HCC who underwent LR. Preoperative malnutrition was associated with the treatment strategies for intrahepatic recurrence and the rate of extrahepatic recurrence in this population.

Indexed as

Carcinoma, HepatocellularHepatectomyLiver NeoplasmsMalnutritionAgedAged, 80 and overAge FactorsDisease-Free SurvivalFemaleHumansMaleMiddle AgedNeoplasm Recurrence, LocalPreoperative PeriodPrognosisRetrospective StudiesGLIM criteriaHepatocellular carcinomaLiver resectionMalnutritionOlder patient

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PMID42295399

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