ArticleClinical research in cardiology : official journal of the German Cardiac Society2026
Invasive ventilation and association with outcomes in heart failure-related cardiogenic shock.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRespiratory failure occurs frequently in cardiogenic shock but with varying severity. It is unknown whether invasive ventilation should be used strictly, reserved for severe respiratory failure, or liberally, reducing stress and increasing compliance with intensive care procedures. Aim of this study was to evaluate the impact of invasive ventilation on outcomes in patients with heart failure-related cardiogenic shock across the severity of respiratory failure.
methodsPatients with heart failure-related cardiogenic shock treated 2010-2021 in 16 tertiary care centers in five countries were enrolled. Cox regression models were constructed to assess the impact of overall invasive ventilation and invasive ventilation stratified by PaO
resultsOf N = 1010 patients (median age 64 years, 724 (71.7%) male), 659 patients (65.2%) received invasive ventilation. In patients receiving invasive ventilation, 30-day mortality was 1.67 times higher (95% confidence interval (CI) 1.26-2.22, p < 0.001) than in patients without invasive ventilation. Although patients with a worse PaO
conclusionsIn patients with cardiogenic shock, invasive ventilation was associated with higher mortality, with a non-significant trend towards higher mortality even in patients with preserved gas exchange. The results call for further analyses on this topic, specifically to clarify whether dedicated ventilator settings or weaning strategies may improve outcomes for affected patients.
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