Evidence map›Paper›PMID 42295234›Full record

ArticleBehavioral neuroscience2026

Biological sex and normative cognitive aging across spatial learning, flexibility, and working memory in Fischer 344 rats.

Zahra Faghihi, David J Horovitz, Lori A Newman, Peter J Vento, Joseph A McQuail

Abstract read
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In one paragraph

Article in Behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zahra FaghihiDepartment of Psychology, University of South Carolina.
David J HorovitzDepartment of Pharmacology, Physiology, and Neuroscience, University of South Carolina School of Medicine.
Lori A NewmanDepartment of Psychological Science, Vassar College.
Peter J VentoDepartment of Psychology, University of South Carolina.ORCID 0000-0002-7279-8790
Joseph A McQuailDepartment of Pharmacology, Physiology, and Neuroscience, University of South Carolina School of Medicine.

Funding

Targeting NMDA Receptors and Brain Estradiol to Rescue Memory in Aging FemalesP20GM109091 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI RONINSON, IGOR B · 2014 to 2024
$25.2M
Epigenetic mechanisms of stress and age-related cognitive declineK01AG061263 · NIA · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MCQUAIL, JOSEPH ALOYSIUS · 2019 to 2023
$582k
NIA NIH HHS K01 AG061263NIGMS NIH HHS P20 GM109091NIH HHS
6 · The paper itself

Abstract

Aging is associated with decline in spatial learning, cognitive flexibility, and working memory, yet the extent to which biological sex modulates changes in cognitive function remains unresolved. While sex differences are evident in pathological brain aging, sparse insights from healthy aging populations suggest that sex effects on cognition are modest and domain specific. To systematically test effects of biological sex across the lifespan on specific aspects of cognitive function, we examined age- and sex-related changes in spatial cognition in a large cohort of Fischer 344 rats (

Indexed as

AgingCognitive AgingMemory, Short-TermSpatial LearningAge FactorsAnimalsCognitionCognitive FlexibilityFemaleMaleMaze LearningRatsRats, Inbred F344Reversal LearningSex Characteristics

Identifiers

PMID42295234
PMCPMC13271161

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.