Evidence map›Paper›PMID 42295134›Full record

ArticleJournal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]2026

Effects of Overnight Whitening Pens on Hydrogen Peroxide Penetration, Color Change, and Enamel Surface Properties.

Iara María Ersilia Lima De León, Laryssa Mylenna Madruga Barbosa, Gabrielle Gomes Centenaro, Mariana Evangelista Santos, Sônia Saeger Meireles, Alessandro D Loguercio

Abstract read
In one paragraph

Article in Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Iara María Ersilia Lima De LeónDepartment of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Paraná, Brazil.ORCID https://orcid.org/0009-0008-3501-0299
Laryssa Mylenna Madruga BarbosaDepartment of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Paraná, Brazil.ORCID https://orcid.org/0000-0001-6226-3672
Gabrielle Gomes CentenaroDepartment of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Paraná, Brazil.ORCID https://orcid.org/0000-0002-6844-202X
Mariana Evangelista SantosDepartment of Restorative Dentistry, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.ORCID https://orcid.org/0000-0002-4282-760X
Sônia Saeger MeirelesDepartment of Restorative Dentistry, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.ORCID https://orcid.org/0000-0001-7328-2991
Alessandro D LoguercioDepartment of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Paraná, Brazil.ORCID https://orcid.org/0000-0001-9880-4856

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 304444/2025-1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001
6 · The paper itself

Abstract

objectiveTo evaluate hydrogen peroxide (HP) permeability into the pulp chamber, objective color change, and enamel surface morphology after overnight use of over-the-counter (OTC) whitening pens. MATERIALS AND

methodsFifty sound premolars were assigned to five groups (n = 10): control, Optic White Pen LED (OW), Colgate Luminous White Whitening Pen (LW), Equate Teeth Whitening Kit (EQ), and Whiteness Perfect 10% (WP). Fifteen molars were used for enamel surface analyses (microhardness and roughness). Products were applied for 8 h/day for 10 days. HP penetration (μg/mL) and color change (ΔE

resultsEQ showed the highest HP concentration and the lowest pH. HP penetration was significantly higher for EQ and lowest for WP (p < 0.05). No significant differences in ΔE

conclusionsOvernight OTC whitening pens showed comparable cumulative bleaching efficacy. However, EQ resulted in greater pulpal HP penetration and enamel softening. CLINICAL SIGNIFICANCE: Prolonged overnight OTC whitening pen use may increase pulpal exposure and enamel softening risk, reinforcing cautious use and professional supervision.

Indexed as

Dental EnamelHydrogen PeroxideTooth BleachingTooth Bleaching AgentsColorHumansSurface PropertiesHydrogen PeroxideTooth Bleaching Agentsdental enamel permeabilityenamel surface propertieshydrogen peroxidetooth whiteningwhitening pens

Identifiers

PMID42295134
PMCPMC13576799

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.