Evidence map›Paper›PMID 42295039›Full record

ArticleInternational journal of rheumatic diseases2026

Interstitial Lung Disease in Rheumatoid Arthritis: Incidence and Outcomes in Western Australia.

Hari Prasanna, Charles Inderjeeth, David B Preen, Johannes Nossent

Abstract read
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Article in International journal of rheumatic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Hari PrasannaFiona Stanley Hospital, Perth, Western Australia, Australia.ORCID https://orcid.org/0009-0006-6396-4167
Charles InderjeethMedical School, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0003-0535-963X
David B PreenSchool of Population and Global Health, University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0002-2982-2169
Johannes NossentMedical School, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0002-2833-7997

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo determine the incidence, risk factors for, and mortality from interstitial lung disease (ILD) in patients with Rheumatoid Arthritis (RA) in Western Australia (WA).

methodsA retrospective statewide cohort study of ILD in patients with RA (n = 5971) and age/sex matched controls (n = 20 830) hospitalized between 1985 and 2014. ILD was identified based on validated algorithms. ILD incidence (IR) per 1000 person-years (PY), odds ratio (OR) for risk factors and respiratory complications, and mortality rate (MR) per 1000 PY were estimated with 95% confidence intervals (CI).

resultsThe IR of ILD in patients with RA (RAILD+) was increased (IR ratio 8.02, CI 6.28-10.32) and stable over 30 years. Age (OR 1.02, CI 1.01-1.03), smoking (OR 1.97, CI 1.48-2.63), and scleritis (OR 3.84, CI 1.86-7.94) were independent risk factors for ILD. Pulmonary infections, oxygen dependence, and lung cancer occurred as frequently in RAILD+ and CoILD+ but at higher rates than in participants without ILD in each group. MR for RAILD+ patients was higher than for RA patients not developing ILD (99.9 vs. 50.8; p < 0.01), but lower than for CoILD+ (166.3 vs. 99.9, p < 0.01).

conclusionThe incidence of ILD among patients with RA was stably increased over time. ILD increased respiratory morbidity and mortality in both RA and controls. Smoking cessation and early detection could reduce the risk and severity of ILD.

Indexed as

Arthritis, RheumatoidLung Diseases, InterstitialAdultAgedFemaleHumansIncidenceMaleMiddle AgedOdds RatioPrognosisRetrospective StudiesRisk AssessmentRisk FactorsSmokingTime Factorsepidemiologyinterstitial lung diseasemortalityrheumatoid arthritisrisk factors

Identifiers

PMID42295039
PMCPMC13267679

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.