Evidence map›Paper›PMID 42295006›Full record

SynthesisProceedings (Baylor University. Medical Center)2026

Early versus late oral anticoagulants after acute ischemic stroke in atrial fibrillation patients: a meta-analysis of randomized controlled trials.

AlMothana Manasrah, Mohammad Tanashat, Ahmed Mazen Amin, Maram Albandak, Mohamed Abuelazm, Afzal Ur Rehman, Yazan A Al-Ajlouni

Abstract readMeta-AnalysisSystematic ReviewReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Proceedings (Baylor University. Medical Center), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Poststroke anticoagulation is timeless.Proceedings (Baylor University. Medical Center) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

AlMothana ManasrahCardiovascular Department, United Health Services - Wilson Medical Center, Johnson City, New York, USA.
Mohammad TanashatFaculty of Medicine, Yarmouk University, Irbid, Jordan.
Ahmed Mazen AminFaculty of Medicine, Mansoura University, Mansoura, Egypt.
Maram AlbandakDepartment of Internal Medicine, University of Toledo, Toledo, Ohio, USA.
Mohamed AbuelazmFaculty of Medicine, Tanta University, Tanta, Egypt.
Afzal Ur RehmanCardiovascular Department, United Health Services - Wilson Medical Center, Johnson City, New York, USA.
Yazan A Al-AjlouniDepartment of Rehabilitation Medicine, Montefiore Medical Center, Bronx, New York, USA.ORCID 0000-0002-1718-4964

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) occurs in about 20% of ischemic stroke cases. Although oral anticoagulants (OACs) reduce stroke risk in AF, the optimal timing for starting them after acute ischemic stroke remains uncertain, with varying recommendations across guidelines.

methodsA systematic review and meta-analysis of randomized controlled trials was conducted using PubMed, Scopus, Web of Science, EMBASE, and Cochrane CENTRAL through October 2024. Studies included adults with AF and recent ischemic stroke, comparing early versus late OAC initiation. The primary outcome was recurrent ischemic stroke. Risk of bias was assessed using the Cochrane RoB2 tool.

resultsThree trials with 6522 patients were included. There were no significant differences between early and late OAC initiation in recurrent ischemic stroke (relative risk [RR] 0.82; 95% confidence interval [CI] 0.61-1.11;

conclusionEarly OAC initiation after ischemic stroke in AF appears as safe as later initiation, without higher bleeding or mortality risks. Given the elevated risk of early recurrence, prompt anticoagulation may be beneficial but requires further confirmation.

Indexed as

AnticoagulantsAtrial FibrillationIschemic StrokeAdministration, OralHumansRandomized Controlled Trials as TopicTime FactorsAnticoagulantsAnticoagulationatrial fibrillationdelayed treatmentearly treatmentmeta-analysistiming

Identifiers

PMID42295006
PMCPMC13523930

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.