Evidence map›Paper›PMID 42294876›Full record

ReviewJournal of virology2026

Mapping the monoclonal antibody landscape of human cytomegalovirus.

Maria K McClave, Ekaterina E Heldwein

Abstract readReview
In one paragraph

Review in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Maria K McClaveDepartment of Molecular Biology and Microbiology and Graduate Program in Molecular Microbiology, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0002-9255-0936
Ekaterina E HeldweinDepartment of Molecular Biology and Microbiology and Graduate Program in Molecular Microbiology, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, USA.ORCID 0000-0003-3113-6958

Funding

Structure, antigenicity, and function of HCMV fusogen gBR01AI164698 · NIAID · TUFTS UNIVERSITY BOSTON · PI HELDWEIN, EKATERINA · 2021 to 2025
$3.4M
Structural and antigenic characterization of human cytomegalovirus gBF31AI179031 · NIAID · TUFTS UNIVERSITY BOSTON · PI MCCLAVE, MARIA KRASILNIKOV · 2024 to 2025
$91k
NIAID NIH HHS F31 AI179031NIAID NIH HHS R01 AI164698NIH HHS F31AI179031NIH HHS R01AI164698
6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is a major cause of congenital disease and a significant threat to immunocompromised individuals, particularly transplant recipients and neonates. Over the past five decades, numerous monoclonal antibodies (mAbs) targeting various HCMV antigens have been isolated. Here, we present a comprehensive review of HCMV-specific mAbs isolated from the 1980s to the present, detailing their target antigens, epitopes, neutralizing activity, and potential clinical applications. This review integrates historical discoveries with recent structural and functional studies, highlighting trends that may inform the development of anti-HCMV therapeutics and prophylactics.

Indexed as

Antibodies, MonoclonalAntibodies, ViralCytomegalovirusCytomegalovirus InfectionsAnimalsAntibodies, NeutralizingAntigens, ViralEpitope MappingEpitopesHumansAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralAntigens, ViralEpitopeseffector functionsgBgH/gLgM/gNHCMVmonoclonal antibodyneutralizationnon-envelope antigenspentamertrimer

Identifiers

PMID42294876
PMCPMC13386992

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.