Evidence map›Paper›PMID 42294856›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2026

Combined androgen excess polycystic ovary syndrome and obesity are associated with elevated beat-to-beat blood pressure variability in adult women.

Benjamin E Young, Abigail Colburn, Zachary R Oldham, Danielle Berbrier, Charlotte W Usselman, Tori Stone, Paul J Fadel, Nina S Stachenfeld

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Benjamin E YoungDepartment of Applied Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0003-0239-005X
Abigail ColburnJohn B. Pierce Laboratory, New Haven, Connecticut, United States.
Zachary R OldhamDepartment of Kinesiology, University of Texas at Arlington, Arlington, Texas, United States.ORCID 0009-0001-6456-4441
Danielle BerbrierDepartment of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-3413-7446
Charlotte W UsselmanDepartment of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-0803-8690
Tori StoneJohn B. Pierce Laboratory, New Haven, Connecticut, United States.ORCID 0000-0002-8831-8659
Paul J FadelDepartment of Kinesiology, University of Texas at Arlington, Arlington, Texas, United States.ORCID 0000-0002-0115-0743
Nina S StachenfeldJohn B. Pierce Laboratory, New Haven, Connecticut, United States.ORCID 0000-0002-6597-5031

Funding

Mechanisms of hypertension in women with polycystic ovary syndromeR01HL135089 · NHLBI · JOHN B. PIERCE LABORATORY, INC. · PI RECKELHOFF, JANE F, STACHENFELD, NINA · 2018 to 2021
$3.5M
Mechanisms and interventions addressing accelerated cardiovascular disease risk in women with endometriosisR01HL161000 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI ALEXANDER, LACY M., STACHENFELD, NINA · 2022 to 2025
$3.3M
American Heart Association (AHA) Postdoctoral FellowshipHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL135089Natural Sciences and Engineering Research Council of Canada (NSERC) RGPIN-2018-05961NHLBI NIH HHS R01 HL135089NHLBI NIH HHS R01 HL161000
6 · The paper itself

Abstract

Androgen excess polycystic ovary syndrome (AE-PCOS) is associated with elevated risk for hypertension and cardiovascular disease. Greater beat-to-beat blood pressure variability (BPV) has emerged as a novel marker of cardiovascular risk. Little is known about beat-to-beat BPV in AE-PCOS, but prior studies suggest blunted baroreflex sensitivity (BRS), a major contributor to beat-to-beat BP regulation. Both obesity and androgen excess are implicated as driving factors of cardiovascular risk in AE-PCOS. We hypothesized that

Indexed as

Blood PressureHypertensionObesityPolycystic Ovary SyndromeAdultBaroreflexCase-Control StudiesFemaleHeart RateHumansPhotoplethysmographyTestosteroneYoung AdultTestosteroneadipositycardiovascular riskhypertensionPCOStestosterone

Identifiers

PMID42294856
PMCPMC13636021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.