ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Biodegradable Zn-Based Implants: Progress, Challenges, and Pathways toward Clinical Translation.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
11 authors.
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Abstract
As a new generation of biomaterials, biodegradable zinc (Zn)-based implants hold substantial promise for clinical use due to their favorable biocompatibility and controllable degradation behavior. This review summarizes recent progress in Zn-based implants, focusing on the physiological roles of Zn, current Zn-based implant systems, and relevant applicable standards. To address the critical challenges faced in practical applications, such as optimizing corrosion rate, antibacterial performance, and biocompatibility, researchers have employed innovative strategies, including alloying (e.g., Zn-Mg, Zn-Mn, Zn-Li), surface modifications, and functional coatings. Meanwhile, a detailed overview is provided of in vitro and in vivo degradation evaluation systems, advances in preclinical animal studies, and the status of clinical trials, together with regulatory requirements for biodegradable metals set by domestic and international authorities. Key mechanistic and translational bottlenecks that currently limit clinical adoption are identified, together with critical directions for the rational design and standardized evaluation of next-generation Zn-based implants.
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