Observational studyJournal of the American Heart Association2026
Long-Term Blood Pressure Variability in Cerebral Amyloid Angiopathy is Associated with Ischemic Brain Injury and Cognitive Decline.
Observational study in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Exploring the intricate interplay between metabolic abnormalities and multidimensional cognitive impairment in stable schizophrenia patients.Translational psychiatry · 2026Observational
- Unfluctuating diastolic pressure, stiff arteries - the unseen culprits behind the curtain of cognitive decline: An observational study.Medicine · 2025Observational
Corrections and comments
- Erratum issued
- Update of
Authors and funding
12 authors.
Funding
Abstract
backgroundLong-term blood pressure variability (BPV) has been proposed as a potential risk factor for dementia and cerebral small vessel disease progression. In this study, we investigate the association between BPV, brain injury, and cognitive decline in probable cerebral amyloid angiopathy (CAA).
methodsUsing a prospective memory clinic cohort, we enrolled 102 participants, including 52 with probable CAA and mild cognitive symptoms. BPV was assessed using a coefficient of variation derived from outpatient BP measurements (median 12) over 5 years before imaging with 3-tesla research magnetic resonance imaging. We measured peak width of skeletonized mean diffusivity and neuroimaging markers of CAA, including lacunes and cortical cerebral microinfarcts. Using regression models, we evaluated the association of BPV with white matter integrity and whether CAA modified this association. We also examined the association of BPV with longitudinal cognitive decline.
resultsSystolic BPV had a dose-dependent association with peak width of skeletonized mean diffusivity (standardized β=0.22, 95% CI: 0.06-0.39,
conclusionsLong-term BPV had a dose-dependent association with altered white matter integrity, ischemic brain injury, and cognitive decline. Controlling BPV might be a potential novel therapeutic target to prevent cognitive decline in memory clinic patients with probable CAA and mild cognitive symptoms.
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